Slow progression of white-matter changes

被引：4
|
作者：
Schmidt, R [1 ]
Schmidt, H
Kapeller, P
Fazekas, F
机构：
[1] Karl Franzens Univ Graz, Dept Neurol, A-8036 Graz, Austria
[2] Karl Franzens Univ Graz, MR Ctr, A-8036 Graz, Austria
[3] Karl Franzens Univ Graz, Inst Med Biochem & Med Mol Biol, A-8036 Graz, Austria
来源：
INTERNATIONAL PSYCHOGERIATRICS | 2003年 / 15卷
关键词：
white-matter lesions; risk factors; cerebral small-vessel disease; cognition;
D O I：
10.1017/S1041610203009153
中图分类号：
B849 [应用心理学];
学科分类号：
040203 ;
摘要：
A three-year follow-up of 273 participants (mean age 60 years) of the Austrian Stroke Prevention Study provides the first information on the rate, clinical predictors, and cognitive consequences of MRI white-matter lesions in elderly individuals without neuropsychiatric disease. Lesion progression was found in 17.9% of individuals over a time period of 3 years. Diastolic blood pressure and early confluent or confluent white-matter hyperintensities at baseline were the only significant predictors of white-matter hyperintensity progression. Lesion progression had no influence on the course of neuropsychologic test performance over the observational period, but the statistical power of this analysis was low.
引用
收藏
页码：173 / 176
页数：4
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