GENOMIC PROFILING OF SINONASAL SQUAMOUS CELL CARCINOMA

被引：29
|
作者：
Lopez, Fernando [1 ]
Llorente, Jose L. [1 ]
Garcia-Inclan, Cristina [1 ]
Alonso-Guervos, Marta [1 ]
Paz Cuesta-Albalad, Mari [1 ]
Fiorentino Fresno, Manuel [2 ]
Alvarez-Marcos, Cesar [1 ]
Suarez, Carlos [1 ]
Hermsen, Mario A. [1 ]
机构：
[1] Hosp Univ Cent Asturias, Inst Univ Oncol Principado Asturias, Dept Otolaryngol, Oviedo, Asturias, Spain
[2] Hosp Univ Cent Asturias, Dept Pathol, Oviedo, Asturias, Spain
来源：
HEAD AND NECK-JOURNAL FOR THE SCIENCES AND SPECIALTIES OF THE HEAD AND NECK | 2011年 / 33卷 / 02期
关键词：
maxillary sinus; ethmoid sinus; squamous cell carcinoma; microarray CGH; MLPA; SPONTANEOUS APOPTOSIS; PARANASAL SINUSES; NASAL CAVITY; P53; CANCER; HEAD; EXPRESSION; ADENOCARCINOMA; PAPILLOMA; THERAPY;
D O I：
10.1002/hed.21417
中图分类号：
R76 [耳鼻咽喉科学];
学科分类号：
100213 ;
摘要：
Background. Sinonasal squamous cell carcinomas (SCCs) are rare tumors with no etiologic link to tobacco and alcohol, as opposed to other SCCs of the head and neck (HNSCC). Little is known about the genetic changes in sinonasal SOC. Methods. DNA copy number changes of sinonasal SCC were analyzed by multiplex ligation-dependent probe amplification (MLPA) and microarray comparative genomic hybridization (maCGH), and results were related to clinicopathologic features. Results. Copy number losses most frequently included genes at 9p21, 13q14, 17p13, 17q21, and 18q11. Frequent gains were observed on 8q24, 11q13, 17q12, 19p13, and 20q11-q13. Conclusion. The genomic profile of sinonasal SCC showed a number of chromosomal regions with copy number changes similar to those known in HNSCC, in spite of the differences in etiology. (C) 2010 Wiley Periodicals, Inc. Head Neck 33: 145153, 2011
引用
收藏
页码：145 / 153
页数：9
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