Novel emerging biomarkers to immunotherapy in kidney cancer

被引：12

作者：

Ged, Yasser ^{[2
]}

Voss, Martin H. ^{[1
]}

机构：

[1] Mem Sloan Kettering Canc Ctr, Dept Med, 300 East 66th St, New York, NY 10065 USA

[2] Johns Hopkins Univ, Dept Med, Baltimore, MD USA

来源：

THERAPEUTIC ADVANCES IN MEDICAL ONCOLOGY | 2021年 / 13卷

关键词：

biomarkers; immune checkpoint; precision medicine; RCC; RENAL-CELL CARCINOMA; LYMPHOCYTE RATIO NLR; PD-L1; EXPRESSION; MUTATIONAL LANDSCAPE; CLINICAL BENEFIT; NIVOLUMAB; BLOCKADE; ASSOCIATION; IPILIMUMAB; SUNITINIB;

D O I：

10.1177/17588359211059367

中图分类号：

R73 [肿瘤学];

学科分类号：

100214 ;

摘要：

The treatment of metastatic renal cell carcinoma has significantly evolved in recent years, particularly with the advent of novel immune checkpoint inhibitors (ICI). Despite the striking benefits observed on a population level, outcomes vary and some patients do not respond to ICI-based regimens, ultimately require salvage therapies. An ever deeper understanding of the disease biology mediated by the development of multiple high-throughput molecular omics has led to significant progress in biomarkers discovery. But despite growing insights into the molecular underpinnings of the tumor microenvironment, biomarkers have not been integrated successfully into clinical practice. In this review, we discuss some of the novel emerging predictive biomarkers to ICIs in metastatic renal cell carcinoma.

引用

页数：13

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