Serum levels of PAPP-A and β-hCG in the first trimester of pregnancy as predictors of unfavourable obstetric outcomes at Hospital Universitario Nuestra Senora de Candelaria

被引：0
作者：
Rodriguez-Zurita, A. [1 ,2 ]
Alvarez, S. Caamina [1 ]
Gomez, T. Gonzalez [2 ]
Garcia, M. Gonzalez [1 ]
Santos, L. Martin [1 ]
Bello, M. A. Garcia [2 ,3 ]
de Basoa, C. Martin Fernandez [4 ]
机构：
[1] Hosp Univ Ntra, Unidad Med Materno Fetal, Serv Obstetr & Ginecol, Sra Candelaria, Santa Cruz de Tenerife, Spain
[2] Univ La Laguna, Santa Cruz De Tenerife, Spain
[3] Hosp Univ Ntra, Unidad Invest, Dept Estadist, Sra Candelaria, Santa Cruz De Tenerife, Spain
[4] Hosp Univ Ntra, Unidad Hormonas Marcadores Tumor Cribaje Prenatal, Serv Analisis Clin, Sra Candelaria, Santa Cruz De Tenerife, Spain
来源：
CLINICA E INVESTIGACION EN GINECOLOGIA Y OBSTETRICIA | 2022年 / 49卷 / 01期
关键词：
PAPP-A; beta-hCG; Adverse obstetric outcomes; pregnancy; HUMAN CHORIONIC-GONADOTROPIN; PLASMA PROTEIN-A; NUCHAL TRANSLUCENCY; 1ST-TRIMESTER; AGE;
D O I：
10.1016/j.gine.2021.100711
中图分类号：
R71 [妇产科学];
学科分类号：
100211 ;
摘要：
Many studies have documented the association between low PAPP-A and beta-hCG values in maternal serum during the first trimester and adverse maternal-foetal effects. To assess this relationship a retrospective analysis of cases and controls was carried out, based on a cohort of patients with a single pregnancy who underwent first-trimester screening between 2017 and 2018. For the group of cases, patients with MoM levels PAPP-A and/or beta-hCG equal to or below the 5 th percentile were selected. The control group was obtained by making a randomized selection of all patients with MoM PAPP-A levels and/or alpha-hCG above that percentile. The analysis of our results showed that in groups with low levels of MoM PAPP-A and MoM beta-hCG, we observed a higher risk of developing restricted intrauterine growth than in the control group (OR: 2.7 and 3.17, respectively). In the MoM PAPP-A <= p5 group we also obtained a 3.8foldhigher risk of global hypertensive states of pregnancy (CI: 1.94-7.83) and 7.9-fold higher risk of antepartum foetal death (CI: 1.09-217.4). These two variables were not statistically significant in the MoM beta-hCG <= p5 group. Our findings confirmed that low levels of PAPP-A and beta-hCG in the serum of pregnant women are associated with a high risk of developing obstetric complications, so they could be used for their early detection and the prevention of poor obstetric results. (C) 2021 Elsevier Espana, S.L.U. All rights reserved.
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页数：8
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