PGC-1α, glucose metabolism and type 2 diabetes mellitus

被引：123
|
作者：
Wu, Haijiang [1 ,2 ]
Deng, Xinna [3 ,4 ]
Shi, Yonghong [1 ,2 ]
Su, Ye [5 ,6 ,7 ]
Wei, Jinying [1 ,2 ]
Duan, Huijun [1 ,2 ]
机构：
[1] Hebei Med Univ, Dept Pathol, Shijiazhuang, Peoples R China
[2] Key Lab Kidney Dis Hebei Prov, Shijiazhuang, Peoples R China
[3] Hebei Gen Hosp, Dept Oncol, Shijiazhuang, Peoples R China
[4] Hebei Gen Hosp, Dept Immunotherapy, Shijiazhuang, Peoples R China
[5] London Hlth Sci Ctr, Lawson Hlth Res Inst, Mathew Mailing Ctr Translat Transplantat Studies, London, ON, Canada
[6] Univ Western Ontario, Dept Med, London, ON, Canada
[7] Univ Western Ontario, Dept Pathol, London, ON, Canada
来源：
JOURNAL OF ENDOCRINOLOGY | 2016年 / 229卷 / 03期
基金：
中国国家自然科学基金;
关键词：
PGC-1; alpha; type 2 diabetes mellitus; glucose metabolism; polymorphism; ACTIVATED-RECEPTOR-GAMMA; HEPATOCYTE NUCLEAR FACTOR-4-ALPHA; REGULATES HEPATIC GLUCONEOGENESIS; COACTIVATOR 1-ALPHA PGC-1-ALPHA; LIPOGENIC GENE-EXPRESSION; C VIRUS-INFECTION; SKELETAL-MUSCLE; INSULIN-RESISTANCE; PROTEIN-KINASE; PPAR-GAMMA;
D O I：
10.1530/JOE-16-0021
中图分类号：
R5 [内科学];
学科分类号：
1002 ; 100201 ;
摘要：
Type 2 diabetes mellitus (T2DM) is a chronic disease characterized by glucose metabolic disturbance. A number of transcription factors and coactivators are involved in this process. Peroxisome proliferator-activated receptor gamma coactivator 1 alpha (PGC-1 alpha) is an important transcription coactivator regulating cellular energy metabolism. Accumulating evidence has indicated that PGC-1 alpha is involved in the regulation of T2DM. Therefore, a better understanding of the roles of PGC-1 alpha may shed light on more efficient therapeutic strategies. Here, we review the most recent progress on PGC-1 alpha and discuss its regulatory network in major glucose metabolic tissues such as the liver, skeletal muscle, pancreas and kidney. The significant associations between PGC-1 alpha polymorphisms and T2DM are also discussed in this review.
引用
收藏
页码：R99 / R115
页数：17
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