RETRACTED: Overexpression of SphK1 enhances cell proliferation and invasion in triple-negative breast cancer via the PI3K/AKT signaling pathway (Retracted article. See April, 2017)

被引：30
|
作者：
Li, Jun [1 ]
Song, Zhangjun [2 ]
Wang, Yiyu [1 ]
Yin, Yue [1 ]
Liu, Ying [1 ]
Yuan, Rong [1 ]
Nan, Xing [1 ]
机构：
[1] Shaanxi Prov Tumor Hosp, Tumor Res Ctr, 309 YanTa West Rd, Xian 710061, Peoples R China
[2] Shaanxi Prov Tumor Hosp, Breast Surg Ctr, Xian 710061, Peoples R China
来源：
TUMOR BIOLOGY | 2016年 / 37卷 / 08期
关键词：
Sphingosine kinase 1; Sphingosine-1-phosphate; Triple-negative breast cancer; Chemotherapy; AKT; PI3K; SPHINGOSINE KINASE 1; THERAPEUTIC TARGET; COLON-CANCER; SURVIVAL; 1-PHOSPHATE; EXPRESSION; PROGNOSIS; APOPTOSIS;
D O I：
10.1007/s13277-016-4954-9
中图分类号：
R73 [肿瘤学];
学科分类号：
100214 ;
摘要：
Sphingosine kinase 1 (SphK1) expression is elevated in various cancers and is associated with shorter survival times for patients. However, the molecular mechanism of SphK1 up-regulation in triple-negative breast cancer (TNBC) remains unclear. In this study, we assayed the expression level of SphK1 in TNBC tissues by qRT-PCR and immunohistochemistry. The level of S1P was quantified by ELISA in the serum of TNBC patients. Our results found that the levels of SphK1 and S1P were significantly increased in TNBC patients compared with normal control. Furthermore, knockdown of SphK1 with siRNA decreased TNBC cell proliferation and inhibited cell migration/invasion. These data suggest that SphK1 has an important role in TNBC and presents an attractive therapeutic target for the treatment for TNBC.
引用
收藏
页码：10587 / 10593
页数：7
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