Tumor size is associated with the systemic inflammatory response but not survival in patients with primary operable colorectal cancer

被引：37

作者：

Crozier, Joseph Em ^{[1
]}

McMillan, Donald C. ^{[1
]}

McArdle, Colin S. ^{[1
]}

Angerson, Wilson J. ^{[1
]}

Anderson, John H. ^{[1
]}

Horgan, Paul G. ^{[1
]}

Mckee, Ruth F. ^{[1
]}

机构：

[1] Royal Infirm, Univ Dept Surg, Glasgow G31 2ER, Lanark, Scotland

来源：

JOURNAL OF GASTROENTEROLOGY AND HEPATOLOGY | 2007年 / 22卷 / 12期

关键词：

colorectal cancer; C-reactive protein; TNM stage; tumor diameter;

D O I：

10.1111/j.1440-1746.2006.04792.x

中图分类号：

R57 [消化系及腹部疾病];

学科分类号：

摘要：

Aim: To examine the relationship between tumor diameter, C-reactive protein concentrations and survival in patients undergoing surgery for colorectal cancer. Method: Tumor diameter and pathological characteristics of the resected specimen were assessed in 227 patients. Circulating concentrations of C-reactive protein were measured prior to surgery. Results: Ninety-six patients had an elevated C-reactive protein concentration (> 10 mg/L) prior to surgery. Tumor size was associated with an elevated C-reactive protein concentration (P < 0.001). C-reactive protein concentrations (P < 0.001) were associated with poorer cancer-specific survival. Conclusion: Prior to surgery, the maximal tumor diameter is associated with an elevated preoperative C-reactive protein concentration but not survival in patients with primary operable colorectal cancer.

引用

页码：2288 / 2291

页数：4

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