Modelling approaches for linking the residual concentrations of antibiotics in soil with antibiotic properties and land-use types in the largest urban agglomerations in China: A review

Persistently high concentrations of antibiotics have been reported in soils worldwide due to the intensive use of veterinary antibiotics, and continuous adsorption and transport of various antibiotics in soils occur, posing a significant threat to the environment and human health. This study systematically reviews the spatial distribution and ecological risk of four commonly detected antibiotic residues in soil in China, including sulphonamides (SAs), fluoroquinolones (FQs), tetracyclines (TCs) and macrolides (MLs), using various models, such as redundancy analysis (RDA), principal coordinate analysis (PCoA) and structural equation modelling (SEM). Antibiotic residual concentration data were obtained from relevant repositories and the literature. The results suggest a high level of antibiotic pollution and ecological risk in the largest urban agglomerations (LUAs), including Beijing-Tianjin-Hebei (BTH), Yangtze River Delta (YRD) and Guangdong-Hong Kong-Macao Greater Bay Area (GBA), with a 100% detection rate. SAs, FQs, TCs and MLs were the dominant antibiotic residues in soils, mainly attributed to manure fertilization and wastewater reuse in agriculture. These antibiotic concentrations ranged from 10(-3 )to 10(3) mu g kg(-1), and their ecological risk varied significantly across different regions of China, with SAs posing the most serious ecological risk to the soil environment (p < 0.05). These models established a significant association (p < 0.05) between the physicochemical properties of antibiotics and land-use type (LUT) with antibiotic residues in soil. The structure of the antibiotic exerted the greatest influence on antibiotic residues, followed by the LUT, while regional differences had the weakest effect.