Altered functional connectivity during spatial working memory in children with heavy prenatal alcohol exposure

被引:22
作者
Infante, M. Alejandra [1 ]
Moore, Eileen M. [2 ]
Bischoff-Grethe, Amanda [1 ]
Tapert, Susan F. [1 ]
Mattson, Sarah N. [2 ]
Riley, Edward P. [2 ]
机构
[1] Univ Calif San Diego, Dept Psychiat, 9500 Gilman Dr,MC 0405, La Jolla, CA 92093 USA
[2] San Diego State Univ, Dept Psychol, Ctr Behav Teratol, San Diego, CA 92182 USA
关键词
Fetal alcohol spectrum disorders (FASD); Spatial working memory; Fronto-parietal network; Functional connectivity; fMRI; SPECTRUM DISORDERS; PSYCHOPHYSIOLOGICAL INTERACTIONS; NEUROBEHAVIORAL PROFILE; BRAIN; FMRI; DEFICITS; ATTENTION; CORTEX; MANIPULATION; REGISTRATION;
D O I
10.1016/j.alcohol.2017.05.002
中图分类号
R194 [卫生标准、卫生检查、医药管理];
学科分类号
摘要
Individuals prenatally exposed to alcohol often have impaired spatial working memory (SWM). This study examines functional connections of frontal and parietal regions that support SWM in children with and without prenatal alcohol exposure. Children ages 10 to 16 with histories of heavy prenatal alcohol exposure (AE group; n = 18) and controls (CON group; n = 19) underwent functional magnetic resonance imaging (fMRI) while performing a SWM task. Whole brain task-related functional connectivity of bilateral dorsolateral prefrontal cortex (DLPFC) and posterior parietal cortex (PPC) seed regions were estimated for each participant using a psychophysiological interaction approach. Children in the AE group were less accurate than children in the CON group when performing the SWM task (p = 0.008). Positive coupling between bilateral DLPFC seeds and regions within the fronto-parietal network was observed in the CON group, whereas the AE group showed negative connectivity. In contrast to the CON group, the AE group showed positive connectivity between PPC seeds and frontal lobe regions. Across seeds, decreased negative coupling with regions outside the fronto-parietal network (e.g., left middle occipital gyrus) were observed in the AE group relative to the CON group. Functional data clusters were considered significant at p < 0.05. Overall findings suggest that localized alterations in neural activity, aberrant fronto-parietal network synchrony, and poor coordination of neural responses with regions outside of this network may help explain SWM deficits in individuals with a history of heavy prenatal alcohol exposure. (C) 2017 Elsevier Inc. All rights reserved.
引用
收藏
页码:11 / 21
页数:11
相关论文
共 50 条
  • [41] Childhood exposure to organophosphate pesticides: Functional connectivity and working memory in adolescents
    Gao, Yuanyuan
    Li, Rihui
    Ma, Qianheng
    Baker, Joseph M.
    Rauch, Stephen
    Gunier, Robert B.
    Mora, Ana M.
    Kogut, Katherine
    Bradman, Asa
    Eskenazi, Brenda
    Reiss, Allan L.
    Sagiv, Sharon K.
    NEUROTOXICOLOGY, 2024, 103 : 206 - 214
  • [42] Functional connectivity during working memory maintenance
    Gazzaley A.
    Rissman J.
    D'Esposito M.
    Cognitive, Affective, & Behavioral Neuroscience, 2004, 4 (4) : 580 - 599
  • [43] Impact of prenatal cannabis exposure on functional connectivity of the salience network in children
    Faraj, Mohammed M.
    Evanski, Julia
    Zundel, Clara G.
    Peters, Craig
    Brummelte, Susanne
    Lundahl, Leslie
    Marusak, Hilary A.
    JOURNAL OF NEUROSCIENCE RESEARCH, 2023, 101 (01) : 162 - 171
  • [44] Functional Connectivity of Cognitive Brain Networks in Schizophrenia during a Working Memory Task
    Godwin, Douglass
    Ji, Andrew
    Kandala, Sridhar
    Mamah, Daniel
    FRONTIERS IN PSYCHIATRY, 2017, 8
  • [45] Characteristics of sleep in children with heavy prenatal alcohol exposure
    Inkelis, Sarah M.
    Soja, Jacqueline
    Mattson, Sarah N.
    Chambers, Christina D.
    Bhattacharjee, Rakesh
    Thomas, Jennifer D.
    ALCOHOL-CLINICAL AND EXPERIMENTAL RESEARCH, 2024, 48 (05): : 928 - 943
  • [46] Age-related alterations in functional connectivity patterns during working memory encoding of emotional items
    Ziaei, Maryam
    Salami, Alireza
    Persson, Jonas
    NEUROPSYCHOLOGIA, 2017, 94 : 1 - 12
  • [47] Functional brain connectivity at rest changes after working memory training
    Jolles, Dietsje D.
    van Buchem, Mark A.
    Crone, Eveline A.
    Rombouts, Serge A. R. B.
    HUMAN BRAIN MAPPING, 2013, 34 (02) : 396 - 406
  • [48] Altered brain white matter connectome in children and adolescents with prenatal alcohol exposure
    Long, Xiangyu
    Little, Graham
    Treit, Sarah
    Beaulieu, Christian
    Gong, Gaolang
    Lebel, Catherine
    BRAIN STRUCTURE & FUNCTION, 2020, 225 (03) : 1123 - 1133
  • [49] Prospective Memory Impairment in Children with Prenatal Alcohol Exposure
    Lewis, Catherine E.
    Thomas, Kevin G. F.
    Molteno, Christopher D.
    Kliegel, Matthias
    Meintjes, Ernesta M.
    Jacobson, Joseph L.
    Jacobson, Sandra W.
    ALCOHOLISM-CLINICAL AND EXPERIMENTAL RESEARCH, 2016, 40 (05) : 969 - 978
  • [50] Sex differences in hippocampal connectivity during spatial long-term memory
    Spets, Dylan S.
    Fritch, Haley A.
    Slotnick, Scott D.
    HIPPOCAMPUS, 2021, 31 (07) : 669 - 676