Sphingomyelin-dependence of cholesterol efflux mediated by ABCG1
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作者:
Sano, Osamu
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机构:Kyoto Univ, Grad Sch Architecture, Biochem Cellular Lab, Div Appl Life Sci, Kyoto 606, Japan
Sano, Osamu
Kobayashi, Aya
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机构:Kyoto Univ, Grad Sch Architecture, Biochem Cellular Lab, Div Appl Life Sci, Kyoto 606, Japan
Kobayashi, Aya
Nagao, Kohjiro
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机构:Kyoto Univ, Grad Sch Architecture, Biochem Cellular Lab, Div Appl Life Sci, Kyoto 606, Japan
Nagao, Kohjiro
Kumagai, Keigo
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机构:Kyoto Univ, Grad Sch Architecture, Biochem Cellular Lab, Div Appl Life Sci, Kyoto 606, Japan
Kumagai, Keigo
Kioka, Noriyuki
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机构:Kyoto Univ, Grad Sch Architecture, Biochem Cellular Lab, Div Appl Life Sci, Kyoto 606, Japan
Kioka, Noriyuki
Hanada, Kentaro
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机构:Kyoto Univ, Grad Sch Architecture, Biochem Cellular Lab, Div Appl Life Sci, Kyoto 606, Japan
Hanada, Kentaro
Ueda, Kazumitsu
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Kyoto Univ, Grad Sch Architecture, Biochem Cellular Lab, Div Appl Life Sci, Kyoto 606, JapanKyoto Univ, Grad Sch Architecture, Biochem Cellular Lab, Div Appl Life Sci, Kyoto 606, Japan
Ueda, Kazumitsu
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Matsuo, Michinori
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机构:Kyoto Univ, Grad Sch Architecture, Biochem Cellular Lab, Div Appl Life Sci, Kyoto 606, Japan
Matsuo, Michinori
机构:
[1] Kyoto Univ, Grad Sch Architecture, Biochem Cellular Lab, Div Appl Life Sci, Kyoto 606, Japan
[2] Inst Natl Infect Dis, Dept Biochem & Cell Biol, Tokyo 162, Japan
ATP binding cassette A1;
ceramide transfer protein;
detergent-resistant membrane;
raft;
D O I:
10.1194/jlr.M700139-JLR200
中图分类号:
Q5 [生物化学];
Q7 [分子生物学];
学科分类号:
071010 ;
081704 ;
摘要:
ABCG1, one of the half-type ATP binding cassette (ABC) proteins, mediates the efflux of cholesterol to HDL and functions in the reverse cholesterol transport from peripheral cells to the liver. We have shown that ABCG1 mediates the efflux of not only cholesterol but also sphingomyelin (SM) and phosphatidylcholine. Because SM preferentially associates with cholesterol, we examined whether it plays an important role in the ABCG1-mediated efflux of cholesterol. The efflux of cholesterol and SM mediated by ABCG1 was reduced in a mutant CHO-K1 cell line, LY-A, in which the cellular SM level is reduced because of a mutation of the ceramide transfer protein CERT. In contrast, CHO-K1 cells overexpressing CERT showed an increased efflux of cholesterol and SM mediated by ABCG1. The sensitivity of cells to methyl-beta-cyclodextrin suggested that cholesterol in nonraft domains was increased due to the disruption of raft domains in LY-A cells. These results suggest that the ABCG1-mediated efflux of cholesterol and SM is dependent on the cellular SM level and distribution of cholesterol in the plasma membrane.
机构:
Zhejiang Univ, Coll Med, Affiliated Hosp 1, Dept Endocrinol, Hangzhou 310003, Zhejiang, Peoples R ChinaUniv Hong Kong, Queen Mary Hosp, Dept Med, Hong Kong, Hong Kong, Peoples R China
Xu, Mingzhi
Zhou, Huali
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机构:
Zhejiang Univ, Coll Med, Affiliated Hosp 1, Dept Endocrinol, Hangzhou 310003, Zhejiang, Peoples R ChinaUniv Hong Kong, Queen Mary Hosp, Dept Med, Hong Kong, Hong Kong, Peoples R China
Zhou, Huali
Tan, Kathryn C. B.
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机构:
Univ Hong Kong, Queen Mary Hosp, Dept Med, Hong Kong, Hong Kong, Peoples R ChinaUniv Hong Kong, Queen Mary Hosp, Dept Med, Hong Kong, Hong Kong, Peoples R China
Tan, Kathryn C. B.
Guo, Renyong
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机构:
Zhejiang Univ, Coll Med, Affiliated Hosp 1, Dept Clin Biochem, Hangzhou 310003, Zhejiang, Peoples R ChinaUniv Hong Kong, Queen Mary Hosp, Dept Med, Hong Kong, Hong Kong, Peoples R China
Guo, Renyong
Shiu, Sammy W. M.
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机构:
Univ Hong Kong, Queen Mary Hosp, Dept Med, Hong Kong, Hong Kong, Peoples R ChinaUniv Hong Kong, Queen Mary Hosp, Dept Med, Hong Kong, Hong Kong, Peoples R China
Shiu, Sammy W. M.
Wong, Ying
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机构:
Univ Hong Kong, Queen Mary Hosp, Dept Med, Hong Kong, Hong Kong, Peoples R ChinaUniv Hong Kong, Queen Mary Hosp, Dept Med, Hong Kong, Hong Kong, Peoples R China
机构:
Harbin Med Univ, Affiliated Hosp 1, Harbin 150001, Heilongjiang, Peoples R ChinaHarbin Med Univ, Affiliated Hosp 1, Harbin 150001, Heilongjiang, Peoples R China
Liang, Xiaofei
Wang, Chao
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机构:
Harbin Med Univ, Affiliated Hosp 1, Harbin 150001, Heilongjiang, Peoples R ChinaHarbin Med Univ, Affiliated Hosp 1, Harbin 150001, Heilongjiang, Peoples R China
Wang, Chao
Sun, Yan
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Harbin Med Univ, Affiliated Hosp 1, Harbin 150001, Heilongjiang, Peoples R ChinaHarbin Med Univ, Affiliated Hosp 1, Harbin 150001, Heilongjiang, Peoples R China
Sun, Yan
Song, Wei
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Harbin Med Univ, Affiliated Hosp 1, Harbin 150001, Heilongjiang, Peoples R ChinaHarbin Med Univ, Affiliated Hosp 1, Harbin 150001, Heilongjiang, Peoples R China
Song, Wei
Lin, Jing
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机构:
Harbin Med Univ, Affiliated Hosp 1, Harbin 150001, Heilongjiang, Peoples R ChinaHarbin Med Univ, Affiliated Hosp 1, Harbin 150001, Heilongjiang, Peoples R China
Lin, Jing
Li, Jiashan
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机构:
Harbin Med Univ, Affiliated Hosp 1, Harbin 150001, Heilongjiang, Peoples R ChinaHarbin Med Univ, Affiliated Hosp 1, Harbin 150001, Heilongjiang, Peoples R China
Li, Jiashan
Guan, Xiuru
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机构:
Harbin Med Univ, Affiliated Hosp 1, Harbin 150001, Heilongjiang, Peoples R ChinaHarbin Med Univ, Affiliated Hosp 1, Harbin 150001, Heilongjiang, Peoples R China
机构:
La Jolla Inst Allergy & Immunol, Div Inflammat Biol, La Jolla, CA 92037 USALa Jolla Inst Allergy & Immunol, Div Inflammat Biol, La Jolla, CA 92037 USA
Sag, Duygu
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Cekic, Caglar
Wu, Runpei
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La Jolla Inst Allergy & Immunol, Div Inflammat Biol, La Jolla, CA 92037 USALa Jolla Inst Allergy & Immunol, Div Inflammat Biol, La Jolla, CA 92037 USA
Wu, Runpei
Linden, Joel
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机构:
La Jolla Inst Allergy & Immunol, Div Dev Immunol, La Jolla, CA 92037 USALa Jolla Inst Allergy & Immunol, Div Inflammat Biol, La Jolla, CA 92037 USA
Linden, Joel
Hedrick, Catherine C.
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机构:
La Jolla Inst Allergy & Immunol, Div Inflammat Biol, La Jolla, CA 92037 USALa Jolla Inst Allergy & Immunol, Div Inflammat Biol, La Jolla, CA 92037 USA