Fibroblast growth factor receptor-1 expression in the cortex and hippocampus in Alzheimer's disease

被引：31
|
作者：
Takami, K
Matsuo, A
Terai, K
Walker, DG
McGeer, EG
McGeer, PL
机构：
[1] Univ British Columbia, Kinsmen Lab Neurol Res, Vancouver, BC V6T 1Z3, Canada
[2] Takeda Chem Ind Ltd, Pharmaceut Dev Div, Drug Safety Res Labs, Yodogawa Ku, Osaka 5328686, Japan
[3] Kyoto Univ, Fac Med, Dept Neurol, Sakyo Ku, Kyoto 6068507, Japan
[4] Yamanouchi Pharmaceut Co Ltd, Inst Drug Discovery Res, Pharmacol Labs, Ibaraki 3058585, Japan
来源：
BRAIN RESEARCH | 1998年 / 802卷 / 1-2期
关键词：
amyloid; tangle; neurodegeneration; astrocyte; membrane protein; in situ hybridization; immunohistochemistry;
D O I：
10.1016/S0006-8993(98)00552-6
中图分类号：
Q189 [神经科学];
学科分类号：
071006 ;
摘要：
Localization of fibroblast growth receptor (FGFR)-1 immunoreactivity was investigated immunochemically in postmortem brain tissue of Alzheimer's disease (AD) and age-matched control cases using a rabbit polyclonal antibody and a mouse monoclonal antibody specific for FGFR-1, In control cases, FGFR-1 immunoreactivity was identified in astrocytes in white matter and in hippocampal pyramidal neurons. In AD cases, the immunoreactivity in reactive astrocytes surrounding senile plaques was increased. The pattern of FGFR-1 immunoreactivity was confirmed in selected cases by in situ hybridization for FGFR-1 mRNA. Immunoreactivity using a monoclonal antibody demonstrated a similar distribution pattern. The localization of FGFR-1 is consistent with previous reports on the involvement of FGF-1 and FGF-2 in AD. (C) 1998 Elsevier Science B.V. All rights reserved.
引用
收藏
页码：89 / 97
页数：9
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