Protein lysine acetylation in cellular function and its role in cancer manifestation

被引：39
作者：
Arif, Mohammed [1 ]
Senapati, Parijat [1 ]
Shandilya, Jayasha [1 ]
Kundu, Tapas K. [1 ]
机构：
[1] Jawaharlal Nehru Ctr Adv Sci Res, Mol Biol & Genet Unit, Transcript & Dis Lab, Bangalore 560064, Karnataka, India
来源：
BIOCHIMICA ET BIOPHYSICA ACTA-GENE REGULATORY MECHANISMS | 2010年 / 1799卷 / 10-12期
关键词：
Acetylation; Cancer; Acetyltransferases; Tumor suppressor; NF-KAPPA-B; HISTONE DEACETYLASE INHIBITORS; TRANSCRIPTIONAL COACTIVATOR PC4; DNA-POLYMERASE-BETA; DAMAGE-DEPENDENT ACETYLATION; PYRUVATE-KINASE ACTIVITY; BASE-EXCISION-REPAIR; EPSTEIN-BARR-VIRUS; P53; ACETYLATION; GENE-EXPRESSION;
D O I：
10.1016/j.bbagrm.2010.10.002
中图分类号：
Q5 [生物化学]; Q7 [分子生物学];
学科分类号：
071010 ; 081704 ;
摘要：
Lysine acetylation appears to be crucial for diverse biological phenomena, including all the DNA-templated processes, metabolism, cytoskeleton dynamics, cell signaling, and circadian rhythm. A growing number of cellular proteins have now been identified to be acetylated and constitute the complex cellular acetylome. Cross-talk among protein acetylation together with other post-translational modifications fine-tune the cellular functions of different protein machineries. Dysfunction of acetylation process is often associated with several diseases, especially cancer. This review focuses on the recent advances in the role of protein lysine acetylation in diverse cellular functions and its implications in cancer manifestation. (C) 2010 Elsevier B.V. All rights reserved.
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收藏
页码：702 / 716
页数：15
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