Synthesis of Heteroarylogous 1H-Indole-3-carboxamidines via a Three-Component Interrupted Ugi Reaction

被引：12
作者：
La Spisa, Fabio [1 ]
Meneghetti, Fiorella [2 ]
Pozzi, Beatrice [1 ]
Tron, Gian Cesare [1 ]
机构：
[1] Univ Piemonte Orientale, Dipartimento Sci Farmaco, I-28100 Novara, Italy
[2] Univ Milan, Dipartimento Sci Farmaceut, I-20133 Milan, Italy
来源：
SYNTHESIS-STUTTGART | 2015年 / 47卷 / 04期
关键词：
isocyanides; secondary amines; Ugi reaction; multicomponent reactions; indoles; DERIVATIVES; ISONITRILE;
D O I：
10.1055/s-0034-1378921
中图分类号：
O62 [有机化学];
学科分类号：
070303 ; 081704 ;
摘要：
A novel one-pot multicomponent synthesis of heteroarylogous 1H-indole-3-carboxamidines starting from readily available N-alkyl-N-(1H-indol-2-ylmethyl) amines, isocyanides, and carbonyl compounds is reported. The strategy exploits the ability of the indole nucleus to interrupt the classical Ugi reaction, by intercepting the nascent nitrilium ion.
引用
收藏
页码：489 / 496
页数：8
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