Randomized Controlled Trial of Prophylactic Negative-Pressure Wound Therapy at Ostomy Closure for the Prevention of Delayed Wound Healing and Surgical Site Infection in Patients with Ulcerative Colitis

被引：35

作者：

Uchino, Motoi ^{[1
]}

Hirose, Kei ^{[1
]}

Bando, Toshihiro ^{[1
]}

Chohno, Teruhiro ^{[1
]}

Takesue, Yoshio ^{[2
]}

Ikeuchi, Hiroki ^{[1
]}

机构：

[1] Hyogo Coll Med, Dept Inflammatory Bowel Dis, Nishinomiya, Hyogo, Japan

[2] Hyogo Coll Med, Dept Infect Control & Prevent, Nishinomiya, Hyogo, Japan

来源：

DIGESTIVE SURGERY | 2016年 / 33卷 / 06期

关键词：

Ostomy closure; Purse-string suture; Negative pressure wound therapy; Ulcerative colitis; VACUUM-ASSISTED CLOSURE; ABDOMINAL CLOSURE; OPEN ABDOMEN; DISEASE; DEVICE;

D O I：

10.1159/000446550

中图分类号：

R57 [消化系及腹部疾病];

学科分类号：

摘要：

Background/Aims: Although negative-pressure wound therapy (NPWT) is likely advantageous for wound healing, the efficacy and safety of its prophylactic use remain unclear for digestive surgery. We performed a prospective randomized controlled study to evaluate the efficacy and safety of this procedure during ileostomy closure. Methods: We conducted a prospective, randomized study between November 2014 and September 2015. Patients with ulcerative colitis scheduled to undergo ileostomy closure with purse-string suture (PSS) were randomly divided into groups with or without NPWT. The primary endpoint was complete wound healing. The secondary endpoints were incidences of wound complications. Results: A total of 31 patients with PSS alone and 28 patients with PSS + NPWT were enrolled. Wound infection was observed in 1 patient in the PSS-alone condition and 3 patients in the PSS + NPWT condition (p = 0.76). The mean duration of complete wound healing was 37.6 +/- 11.7 days in the PSS-alone condition and 33.5 +/- 10.0 days in the PSS + NPWT condition (p = 0.18). Conclusion: Although no adverse effects were observed in this series, the efficacy of PSS + NPWT was not confirmed. Further clarification of the indication of prophylactic NPWT and its efficacy must be obtained, and the efficacy and safety of NPWT in different dirty/infected surgeries should be evaluated. (C) 2016 S. Karger AG, Basel.

引用

页码：449 / 454

页数：6