Metabolic and Nutritional Aspects in Paediatric Patients with Klinefelter Syndrome: A Narrative Review

被引：4
作者：
Mameli, Chiara [1 ]
Fiore, Giulia [1 ]
Sangiorgio, Arianna [1 ]
Agostinelli, Marta [1 ]
Zichichi, Giulia [1 ]
Zuccotti, Gianvincenzo [1 ]
Verduci, Elvira [1 ,2 ]
机构：
[1] Univ Milan, Vittore Buzzi Childrens Hosp, Dept Pediat, I-20154 Milan, Italy
[2] Univ Milan, Dept Hlth Sci, I-20142 Milan, Italy
来源：
NUTRIENTS | 2022年 / 14卷 / 10期
关键词：
Klinefelter syndrome; children; bone metabolism; hypogonadism; body composition; diabetes; metabolic syndrome; cardiovascular risk; hormonal replacement therapy; BONE-MINERAL DENSITY; TESTOSTERONE TREATMENT; BODY-COMPOSITION; RISK-FACTOR; BOYS; ADIPONECTIN; THERAPY; HORMONE; INFANTS; OBESITY;
D O I：
10.3390/nu14102107
中图分类号：
R15 [营养卫生、食品卫生]; TS201 [基础科学];
学科分类号：
100403 ;
摘要：
Klinefelter syndrome is the most common sex chromosomal aneuploidy in males. It is well known that patients with this syndrome have greater mortality and morbidity compared to the general population due to cardiovascular diseases and endocrine metabolism disorders. This augmented risk is due both to hypogonadism and to the syndrome itself. Therefore, correct hormonal replacement therapy and early primary prevention are crucial to these patients. Even though different studies are available on this topic in adult patients, only a few authors have focused on the paediatric population. Thus, in this narrative review, we report the current knowledge of metabolic and nutritional aspects in children with Klinefelter syndrome.
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页数：16
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