Form and function for T cells in health and disease

被引:28
作者
Farber, Donna L. [1 ,2 ,3 ]
机构
[1] Columbia Univ, Irving Med Ctr, Columbia Ctr Translat Immunol, New York, NY 10027 USA
[2] Columbia Univ, Irving Med Ctr, Dept Surg, New York, NY 10027 USA
[3] Columbia Univ, Irving Med Ctr, Dept Microbiol & Immunol, New York, NY 10027 USA
基金
美国国家卫生研究院;
关键词
D O I
10.1038/s41577-019-0267-8
中图分类号
R392 [医学免疫学]; Q939.91 [免疫学];
学科分类号
100102 ;
摘要
Understanding the complexity of T cell subsets and their role in disease has been a continuing effort. In 2019, the field saw a number of important advances in identifying new T cell subsets and functional states associated with immunopathology, described molecular mechanisms involved in T cell dysregulation in infection and cancer, and provided insight into what defines a healthy T cell state.
引用
收藏
页码:83 / 84
页数:2
相关论文
共 10 条
[1]   MHC-II neoantigens shape tumour immunity and response to immunotherapy [J].
Alspach, Elise ;
Lussier, Danielle M. ;
Miceli, Alexander P. ;
Kizhvatov, Ilya ;
DuPage, Michel ;
Luoma, Adrienne M. ;
Meng, Wei ;
Lichti, Cheryl F. ;
Esaulova, Ekaterina ;
Vomund, Anthony N. ;
Runci, Daniele ;
Ward, Jeffrey P. ;
Gubin, Matthew M. ;
Medrano, Ruan F. V. ;
Arthur, Cora D. ;
White, J. Michael ;
Sheehan, Kathleen C. F. ;
Chen, Alex ;
Wucherpfennig, Kai W. ;
Jacks, Tyler ;
Unanue, Emil R. ;
Artyomov, Maxim N. ;
Schreiber, Robert D. .
NATURE, 2019, 574 (7780) :696-+
[2]   TOX for tired T cells [J].
Bordon, Yvonne .
NATURE REVIEWS IMMUNOLOGY, 2019, 19 (08) :476-476
[3]   Follicular Helper CD4 T Cells (TFH) [J].
Crotty, Shane .
ANNUAL REVIEW OF IMMUNOLOGY, VOL 29, 2011, 29 :621-663
[4]   Recurrent group A Streptococcus tonsillitis is an immunosusceptibility disease involving antibody deficiency and aberrant TFH cells [J].
Dan, Jennifer M. ;
Havenar-Daughton, Colin ;
Kendric, Kayla ;
Al-kolla, Rita ;
Kaushik, Kirti ;
Rosales, Sandy L. ;
Anderson, Ericka L. ;
LaRock, Christopher N. ;
Vijayanand, Pandurangan ;
Seumois, Gregory ;
Layfield, David ;
Cutress, Ramsey I. ;
Ottensmeier, Christian H. ;
Arlehamn, Cecilia S. Lindestam ;
Sette, Alessandro ;
Nizet, Victor ;
Bothwell, Marcella ;
Brigger, Matthew ;
Crotty, Shane .
SCIENCE TRANSLATIONAL MEDICINE, 2019, 11 (478)
[5]   Identification of a T follicular helper cell subset that drives anaphylactic IgE [J].
Gowthaman, Uthaman ;
Chen, Jennifer S. ;
Zhang, Biyan ;
Flynn, William F. ;
Lu, Yisi ;
Song, Wenzhi ;
Joseph, Julie ;
Gertie, Jake A. ;
Xu, Lan ;
Collet, Magalie A. ;
Grassmann, Jessica D. S. ;
Simoneau, Tregony ;
Chiang, David ;
Berin, M. Cecilia ;
Craft, Joseph E. ;
Weinstein, Jason S. ;
Williams, Adam ;
Eisenbarth, Stephanie C. .
SCIENCE, 2019, 365 (6456) :883-+
[6]   Follicular helper T cells mediate IgE antibody response to airborne allergens [J].
Kobayashi, Takao ;
Iijima, Koji ;
Dent, Alexander L. ;
Kita, Hirohito .
JOURNAL OF ALLERGY AND CLINICAL IMMUNOLOGY, 2017, 139 (01) :300-+
[7]   Single-cell transcriptomics of human T cells reveals tissue and activation signatures in health and disease [J].
Szabo, Peter A. ;
Levitin, Hanna Mendes ;
Miron, Michelle ;
Snyder, Mark E. ;
Senda, Takashi ;
Yuan, Jinzhou ;
Cheng, Yim Ling ;
Bush, Erin C. ;
Dogra, Pranay ;
Thapa, Puspa ;
Farber, Donna L. ;
Sims, Peter A. .
NATURE COMMUNICATIONS, 2019, 10 (1)
[8]   Effector TH17 Cells Give Rise to Long-Lived TRM Cells that Are Essential for an Immediate Response against Bacterial Infection [J].
Vesely, Maria Carolina Amezcua ;
Pallis, Paris ;
Bielecki, Piotr ;
Low, Jun Siong ;
Zhao, Jun ;
Harman, Christian C. D. ;
Kroehling, Lina ;
Jackson, Ruaidhri ;
Bailis, Will ;
Licona-Limon, Paula ;
Xu, Hao ;
Iijima, Norifumi ;
Pillai, Padmini S. ;
Kaplan, Daniel H. ;
Weaver, Casey T. ;
Kluger, Yuval ;
Kowalczyk, Monika S. ;
Iwasaki, Akiko ;
Pereira, Joao P. ;
Esplugues, Enric ;
Gagliani, Nicola ;
Flavell, Richard A. .
CELL, 2019, 178 (05) :1176-+
[9]   The Transcription Factor Tox2 Drives T Follicular Helper Cell Development via Regulating Chromatin Accessibility [J].
Xu, Wei ;
Zhao, Xiaohong ;
Wang, Xiaoshuang ;
Feng, Han ;
Gou, Mengting ;
Jin, Wei ;
Wang, Xiaohu ;
Liu, Xindong ;
Dong, Chen .
IMMUNITY, 2019, 51 (05) :826-+
[10]   Hobit- and Blimp-1-driven CD4+ tissue-resident memory T cells control chronic intestinal inflammation [J].
Zundler, Sebastian ;
Becker, Emily ;
Spocinska, Marta ;
Slawik, Monique ;
Parga-Vidal, Loreto ;
Stark, Regina ;
Wiendl, Maximilian ;
Atreya, Raja ;
Rath, Timo ;
Leppkes, Moritz ;
Hildner, Kai ;
Lopez-Posadas, Rocio ;
Lukassen, Soeren ;
Ekici, Arif B. ;
Neufert, Clemens ;
Atreya, Imke ;
van Gisbergen, Klaas P. J. M. ;
Neurath, Markus F. .
NATURE IMMUNOLOGY, 2019, 20 (03) :288-+