Comparison of cisplatin-induced nephrotoxicity when using conventional versus short hydration in gastric cancer-a retrospective study

被引：12

作者：

Aoyama, Takeshi ^{[1
,3
]}

Tsunoda, Takashi ^{[1
]}

Kato, Hiroki ^{[1
]}

Hagino, Akane ^{[1
]}

Furutani, Ryota ^{[1
]}

Ito, Kazuyuki ^{[1
]}

Yoshioka, Hidenori ^{[1
]}

Nakamura, Masashi ^{[1
]}

Hiraide, Makoto ^{[1
]}

Kawakami, Kazuyoshi ^{[1
]}

Kobayashi, Kazuo ^{[1
]}

Suzuki, Kenichi ^{[1
]}

Ichimura, Takashi ^{[2
]}

Yamaguchi, Kensei ^{[2
]}

Hama, Toshihiro ^{[1
]}

机构：

[1] Japanese Fdn Canc Res, Canc Inst Hosp, Dept Pharm, Tokyo, Japan

[2] Japanese Fdn Canc Res, Canc Inst Hosp, Dept Gastroenterol Chemotherapy, Tokyo, Japan

[3] 12 Kenichi Suzuki Hoshi Univ, Div Appl Pharmaceut Educ & Res, Shinagawa Ku, Ebara 2-4-41, Tokyo 1428501, Japan

来源：

JOURNAL OF CHEMOTHERAPY | 2020年 / 32卷 / 03期

关键词：

Cisplatin; gastric cancer; hydration; magnesium supplementation; nephrotoxicity; short hydration; PATIENTS RECEIVING CISPLATIN; LUNG-CANCER; PHASE-III; CHEMOTHERAPY; MANNITOL; PHARMACOKINETICS; DIURESIS; REGIMEN; TRIAL;

D O I：

10.1080/1120009X.2020.1713507

中图分类号：

R73 [肿瘤学];

学科分类号：

100214 ;

摘要：

Although a short hydration protocol for cisplatin has been recently developed for use in lung cancer, this has yet to be established for gastric cancer. This study reviewed medical records of patients with gastric cancer who received XPT(capecitabine/cisplatin/trastuzumab) therapy containing cisplatin. Patients received either the conventional or short hydration regimen. Nephrotoxicity was compared between these two regimens by monitoring the serum creatinine. Out of the 26 total patients, 19 received the conventional regimen while 7 received the short hydration regimen. There was a higher nephrotoxicity was observed in the group receiving the conventional regimen (42.1%, 8/19) as compared to the short hydration regimen (0%, 0/7). There was a statistically significant difference in nephrotoxicity between the regimens (P = 0.039). Study results suggest that short hydration may be a feasible regimen for XPT therapy in gastric cancer patients.

引用

页码：144 / 150

页数：7

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