Malignant tumours of the small intestine

被引:43
作者
Reynolds, Ian [1 ]
Healy, Paul [1 ]
Mcnamara, Deborah A. [1 ]
机构
[1] Beaumont Hosp, Dept Colorectal Surg, Dublin 9, Ireland
来源
SURGEON-JOURNAL OF THE ROYAL COLLEGES OF SURGEONS OF EDINBURGH AND IRELAND | 2014年 / 12卷 / 05期
关键词
Small bowel cancer; Small bowel tumours; Adenocarcinoma; Carcinoid tumours; Gastrointestinal stromal tumours; Diagnosis of small bowel tumours; Management of small bowel tumours; SMALL-BOWEL ADENOCARCINOMA; GASTROINTESTINAL STROMAL TUMOR; ADENOMATOUS POLYPOSIS-COLI; PROGNOSTIC-FACTORS; COLORECTAL-CANCER; COMBINATION CHEMOTHERAPY; MOLECULAR-GENETICS; IMATINIB MESYLATE; CARCINOID-TUMOR; UNITED-STATES;
D O I
10.1016/j.surge.2014.02.003
中图分类号
R61 [外科手术学];
学科分类号
摘要
Adenocarcinoma, neuroendocrine tumours, sarcomas and lymphomas are the four most common malignant tumours arising in the small intestine, although over forty different histological subtypes are described. Collectively these account for only 2% of cancers of the digestive system. The incidence of small bowel cancer has increased in recent decades with a four-fold increase in carcinoid tumours. Risk factors for small bowel tumours include coeliac disease, inflammatory bowel disease and a number of genetic abnormalities. The non-specific nature of their symptoms and the difficulty in visualising these tumours with normal endoscopic techniques often results in late diagnosis. Furthermore the paucity of literature on this topic has made it difficult to standardise management. There has however been marked improvement in imaging methods resulting in earlier diagnosis in many cases. As expected, early detection of localised, well differentiated tumours followed by surgical resection with negative margins offers the best chance of long term survival. Better adjuvant treatment, notably for gastrointestinal strornal tumours, has improved 5-year survival rates significantly. Development of surveillance guidelines for at risk populations may be a valuable way of improving early diagnosis of this challenging group of conditions. (C) 2014 Royal College of Surgeons of Edinburgh (Scottish charity number SC005317) and Royal College of Surgeons in Ireland. Published by Elsevier Ltd. All rights reserved.
引用
收藏
页码:263 / 270
页数:8
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