Fatal opiates overdose.: Toxicological identification of various metabolites in a blood sample by GC-MS after silylation

被引：8

作者：

Balíková, M ^{[1
]}

Maresová, V ^{[1
]}

机构：

[1] Charles Univ, Med Fac & Hosp 1, Inst Toxicol & Forens Chem, Prague 12108 2, Czech Republic

来源：

FORENSIC SCIENCE INTERNATIONAL | 1998年 / 94卷 / 03期

关键词：

opiates overdose; ethylmorphine; hydrocodone; dihydrocodeine; codeine; metabolites; gas chromatography mass spectrometry; fatal blood levels;

D O I：

10.1016/S0379-0738(98)00077-2

中图分类号：

DF [法律]; D9 [法律]; R [医药、卫生];

学科分类号：

0301 ; 10 ;

摘要：

A fatal opiates overdose, where ethylmorphine, hydrocodone, dihydrocodeine and codeine were consumed concomitantly, is reported. This case report may contribute to data on fatal blood concentrations of drugs with rare incidence. The relative retention times in capillary gas chromatography and full mass spectra of various opiates in their silylated forms, detected together in one sample, may serve as a helpful analytical reference for clinical and forensic toxicologists. (C) 1998 Elsevier Science Ireland Ltd. All rights reserved.

引用

页码：201 / 209

页数：9

共 16 条

[1]

[Anonymous], 1995, DISPOSITION TOXIC DR

[2]

Casy AF, 1986, OPIOID ANALGESICS CH

[3]

CONE EJ, 1978, DRUG METAB DISPOS, V6, P488

[4]

*DRA, 1996, TIAFT B, V26, P1

[5] SIMULTANEOUS DETERMINATION OF DIHYDROCODEINE AND DIHYDROMORPHINE IN SERUM BY GAS-CHROMATOGRAPHY TANDEM MASS-SPECTROMETRY [J].

HOFMANN, U ;

FROMM, MF ;

JOHNSON, S ;

MIKUS, G .

JOURNAL OF CHROMATOGRAPHY B-BIOMEDICAL APPLICATIONS, 1995, 663 (01) :59-65

[6] EXPLORATION OF THE METABOLISM OF DIHYDROCODEINE VIA DETERMINATION OF ITS METABOLITES IN HUMAN URINE USING MICELLAR ELECTROKINETIC CAPILLARY CHROMATOGRAPHY [J].

HUFSCHMID, E ;

THEURILLAT, R ;

MARTIN, U ;

THORMANN, W .

JOURNAL OF CHROMATOGRAPHY B-BIOMEDICAL APPLICATIONS, 1995, 668 (01) :159-170

[7] ETHYLMORPHINE CONCENTRATIONS IN HUMAN SAMPLES IN AN OVERDOSE CASE [J].

KINTZ, P ;

JAMEY, C ;

MANGIN, P .

ARCHIVES OF TOXICOLOGY, 1994, 68 (03) :210-211

[8]

MILLS T, 1987, INSTRUMENTAL DATA DR

[9]

PFLEGER K, 1992, MASS SPECTRAL GC DAT

[10]

POSSEY BL, 1984, J ANAL TOXICOL, V8, P68

← 1 2 →