MAP kinase phosphatase 1: a novel mediator of biological effects of glucocorticoids?

被引：123
|
作者：
Clark, AR [1 ]
机构：
[1] Univ London Imperial Coll Sci Technol & Med, Fac Med, Kennedy Inst Rheumatol, London W6 8LH, England
来源：
JOURNAL OF ENDOCRINOLOGY | 2003年 / 178卷 / 01期
关键词：
D O I：
10.1677/joe.0.1780005
中图分类号：
R5 [内科学];
学科分类号：
1002 ; 100201 ;
摘要：
Synthetic glucocorticoids (GCs) potently inhibit the expression of pro-inflammatory genes and are widely used in the treatment of inflammatory diseases. However, some patients are resistant to the therapeutic effects of GCs, and many suffer deleterious side effects from these drugs. Furthermore. the precise mechanisms by which GCs inhibit pro-inflammatory gene expression remain unclear. A number of recent papers report that GCs induce the sustained expression of MAP kinase (MAPK) phosphatase 1 (MKP-1), a negative regulator of MAPK signal transduction pathways. The potential relevance of MKP-1 to some of the biological effects of GCs is discussed.
引用
收藏
页码：5 / 12
页数：8
相关论文
共 50 条
  • [41] Essential role of calcium in the regulation of MAP kinase phosphatase-1 expression
    Scimeca, JC
    Servant, MJ
    Dyer, JO
    Meloche, S
    ONCOGENE, 1997, 15 (06) : 717 - 725
  • [42] The wheat MAP kinase phosphatase 1 confers higher lithium tolerance in yeast
    Zaidi, Ikram
    Gonzalez, Asier
    Touzri, Majdi
    Alvarez, Maria C.
    Ramos, Jose
    Masmoudi, Khaled
    Arino, Joaquin
    Hanin, Moez
    FEMS YEAST RESEARCH, 2012, 12 (07) : 774 - 784
  • [43] MAP kinase phosphatase-1, a gatekeeper of the acute innate immune response
    Kirk, Sean G.
    Samavati, Lobelia
    Liu, Yusen
    LIFE SCIENCES, 2020, 241
  • [44] Deficiency of MAP Kinase Phosphatase-1 Induces Pulmonary Hypertension in Mice
    Das, Mita
    Shields, Kristin M.
    Burns, Nana
    Harral, Julie
    Homma, Noriyuki
    Oka, Masahiko
    West, James
    FASEB JOURNAL, 2008, 22
  • [45] GILZ as a Mediator of the Anti-Inflammatory Effects of Glucocorticoids
    Ronchetti, Simona
    Migliorati, Graziella
    Riccardi, Carlo
    FRONTIERS IN ENDOCRINOLOGY, 2015, 6
  • [46] Mechanisms of expression of MAP kinase-phosphatase-1 (MKP-1) and MAP kinase-phosphatase-3 (MKP-3) during hypoxia in neuronal nuclei of newborn piglets
    Mishra, OP
    Delivoria-Papadopoulos, M
    PEDIATRIC RESEARCH, 2004, 55 (04) : 33A - 33A
  • [47] Mice lacking MAP kinase phosphatase-1 have enhanced MAP kinase activity and resistance to diet-induced obesity
    Wu, J. Julie
    Roth, Rachel J.
    Anderson, Ethan J.
    Hong, Eun-Gyoung
    Lee, Mi-Kyung
    Choi, Cheol Soo
    Neufer, P. Darrell
    Shulman, Gerald I.
    Kim, Jason K.
    Bennett, Anton M.
    CELL METABOLISM, 2006, 4 (01) : 61 - 73
  • [48] Glucocorticoids inhibit MAP kinase via increased expression and decreased degradation of MKP-1
    Kassel, O
    Sancono, A
    Krätzschmar, J
    Kreft, B
    Stassen, M
    Cato, ACB
    EMBO JOURNAL, 2001, 20 (24): : 7108 - 7116
  • [49] Mitogen-activated protein kinase phosphatase-1 is a mediator of breast cancer chemoresistance
    Small, George W.
    Shi, Yue Y.
    Higgins, Linda S.
    Orlowski, Robert Z.
    CANCER RESEARCH, 2007, 67 (09) : 4459 - 4466
  • [50] Mitogen-activated protein kinase phosphatase-1 is a mediator of breast cancer chemoresistance
    Orlowski, RZ
    Shi, YY
    Small, GW
    BREAST CANCER RESEARCH AND TREATMENT, 2004, 88 : S31 - S31
12345