MAP kinase phosphatase 1: a novel mediator of biological effects of glucocorticoids?

被引：125
作者：
Clark, AR [1 ]
机构：
[1] Univ London Imperial Coll Sci Technol & Med, Fac Med, Kennedy Inst Rheumatol, London W6 8LH, England
来源：
JOURNAL OF ENDOCRINOLOGY | 2003年 / 178卷 / 01期
关键词：
D O I：
10.1677/joe.0.1780005
中图分类号：
R5 [内科学];
学科分类号：
1002 ; 100201 ;
摘要：
Synthetic glucocorticoids (GCs) potently inhibit the expression of pro-inflammatory genes and are widely used in the treatment of inflammatory diseases. However, some patients are resistant to the therapeutic effects of GCs, and many suffer deleterious side effects from these drugs. Furthermore. the precise mechanisms by which GCs inhibit pro-inflammatory gene expression remain unclear. A number of recent papers report that GCs induce the sustained expression of MAP kinase (MAPK) phosphatase 1 (MKP-1), a negative regulator of MAPK signal transduction pathways. The potential relevance of MKP-1 to some of the biological effects of GCs is discussed.
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页码：5 / 12
页数：8
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