The Role of Gut Microbiota in Atherosclerosis and Hypertension

被引：170

作者：

Ma, Junli ^{[1
]}

Li, Houkai ^{[1
]}

机构：

[1] Shanghai Univ Tradit Chinese Med, Funct Metabol & Gut Microbiome Lab, Inst Interdisciplinary Integrat Med Res, Shanghai, Peoples R China

来源：

FRONTIERS IN PHARMACOLOGY | 2018年 / 9卷

基金：

中国国家自然科学基金;

关键词：

gut microbiota; cardiovascular disease; atherosclerosis; TMAO; bile acids; hypertension; SCFAs; TRIMETHYLAMINE-N-OXIDE; FARNESOID-X-RECEPTOR; CHAIN FATTY-ACIDS; ENDOTOXEMIA-INDUCED INFLAMMATION; CHOLESTEROL-LOWERING EFFICACY; CORONARY-ARTERY-DISEASE; TOLL-LIKE RECEPTORS; REUTERI NCIMB 30242; VITAMIN-D-RECEPTOR; CARDIOVASCULAR-DISEASE;

D O I：

10.3389/fphar.2018.01082

中图分类号：

R9 [药学];

学科分类号：

1007 ;

摘要：

In recent years, accumulating evidence has indicated the importance of gut microbiota in maintaining human health. Gut dysbiosis is associated with the pathogenesis of a number of metabolic diseases including obesity, type 2 diabetes mellitus (T2DM), nonalcoholic fatty liver disease (NAFLD), and cardiovascular diseases (CVDs). Indeed, CVD has become the leading cause of death worldwide, especially in developed countries. In this review, we mainly discuss the gut microbiota-involved mechanisms of CVD focusing on atherosclerosis and hypertension, two major risk factors for serious CVD. Then, we briefly discuss the prospects of gut microbiota-targeted therapeutic strategies for the treatment of CVD in the future.

引用

收藏

页数：14

相关论文

共 174 条

[1] Pathogen recognition and innate immunity [J].

Akira, S ;

Uematsu, S ;

Takeuchi, O .

CELL, 2006, 124 (04) :783-801

[2] Toll-like receptor signalling [J].

Akira, S ;

Takeda, K .

NATURE REVIEWS IMMUNOLOGY, 2004, 4 (07) :499-511

[3] Gut Microbiota in Vascular Disease: Therapeutic Target? [J].

Anbazhagan, A. N. ;

Priyamvada, S. ;

Priyadarshini, M. .

CURRENT VASCULAR PHARMACOLOGY, 2017, 15 (04) :291-295

[4] Effects of antibiotic therapy on outcomes of patients with coronary artery disease - A meta-analysis of randomized controlled trials [J].

Andraws, R ;

Berger, JS ;

Brown, DL .

JAMA-JOURNAL OF THE AMERICAN MEDICAL ASSOCIATION, 2005, 293 (21) :2641-2647

[5] A cell biological view of Toll-like receptor function: regulation through compartmentalization [J].

Barton, Gregory M. ;

Kagan, Jonathan C. .

NATURE REVIEWS IMMUNOLOGY, 2009, 9 (08) :535-542

[6] Trimethylamine-N-Oxide, a Metabolite Associated with Atherosclerosis, Exhibits Complex Genetic and Dietary Regulation [J].

Bennett, Brian J. ;

Vallim, Thomas Q. de Aguiar ;

Wang, Zeneng ;

Shih, Diana M. ;

Meng, Yonghong ;

Gregory, Jill ;

Allayee, Hooman ;

Lee, Richard ;

Graham, Mark ;

Crooke, Rosanne ;

Edwards, Peter A. ;

Hazen, Stanley L. ;

Lusis, Aldons J. .

CELL METABOLISM, 2013, 17 (01) :49-60

[7] Diets high in resistant starch increase plasma levels of trimethylamine-N-oxide, a gut microbiome metabolite associated with CVD risk [J].

Bergeron, Nathalie ;

Williams, Paul T. ;

Lamendella, Regina ;

Faghihnia, Nastaran ;

Grube, Alyssa ;

Li, Xinmin ;

Wang, Zeneng ;

Knight, Rob ;

Jansson, Janet K. ;

Hazen, Stanley L. ;

Krauss, Ronald M. .

BRITISH JOURNAL OF NUTRITION, 2016, 116 (12) :2020-2029

[8] Usual choline and betaine dietary intake and incident coronary heart disease: The Atherosclerosis Risk in Communities (ARIC) Study [J].

Bidulescu A. ;

Chambless L.E. ;

Siega-Riz A.M. ;

Zeisel S.H. ;

Heiss G. .

BMC Cardiovascular Disorders, 7 (1)

[9] Cardiovascular and Antiobesity Effects of Resveratrol Mediated through the Gut Microbiota [J].

Bird, Julia K. ;

Raederstorff, Daniel ;

Weber, Peter ;

Steinert, Robert E. .

ADVANCES IN NUTRITION, 2017, 8 (06) :839-849

[10] Reduced atherosclerosis in MyD88-null mice links elevated serum cholesterol levels to activation of innate immunity signaling pathways [J].

Björkbacka, H ;

Kunjathoor, VV ;

Moore, KJ ;

Koehn, S ;

Ordija, CM ;

Lee, MA ;

Means, T ;

Halmen, K ;

Luster, AD ;

Golenbock, DT ;

Freeman, MW .

NATURE MEDICINE, 2004, 10 (04) :416-421

← 1 2 3 4 5 6 7 8 9 10 →