Chimeric antigen receptors for adoptive T cell therapy in acute myeloid leukemia

被引：78

作者：

Fan, Mingxue ^{[1
]}

Li, Minghao ^{[1
]}

Gao, Lipeng ^{[1
]}

Geng, Sicong ^{[2
]}

Wang, Jing ^{[1
]}

Wang, Yiting ^{[1
]}

Yan, Zhiqiang ^{[1
]}

Yu, Lei ^{[1
]}

机构：

[1] East China Normal Univ, Shanghai Engn Res Ctr Mol Therapeut & New Drug De, Inst Biomed Engn & Technol, Sch Chem & Mol Engn, 3663 Zhongshan Rd, Shanghai 200062, Peoples R China

[2] China Novartis Inst Biomed Res Co Ltd, GDD TRD Chem & Pharmaceut Profiling, 5F,Bldg 3,Novartis Campus 4218 Jinke Rd, Shanghai 201203, Peoples R China

来源：

JOURNAL OF HEMATOLOGY & ONCOLOGY | 2017年 / 10卷

基金：

中国国家自然科学基金;

关键词：

Chimeric antigen receptors; Acute myeloid leukemia; Immunotherapy; ANTITUMOR-ACTIVITY; CYTOSINE-ARABINOSIDE; EFFECTOR FUNCTIONS; MULTIPLE-MYELOMA; NKG2D LIGANDS; CAR THERAPY; ALPHA CHAIN; STEM-CELLS; EXPRESSION; BETA;

D O I：

10.1186/s13045-017-0519-7

中图分类号：

R73 [肿瘤学];

学科分类号：

100214 ;

摘要：

Currently, conventional therapies for acute myeloid leukemia (AML) have high failure and relapse rates. Thus, developing new strategies is crucial for improving the treatment of AML. With the clinical success of anti-CD19 chimeric antigen receptor (CAR) T cell therapies against B-lineage malignancies, many studies have attempted to translate the success of CAR T cell therapy to other malignancies, including AML. This review summarizes the current advances in CAR T cell therapy against AML, including preclinical studies and clinical trials, and discusses the potential AML-associated surface markers that could be used for further CAR technology. Finally, we describe strategies that might address the current issues of employing CAR T cell therapy in AML.

引用

页数：14

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