Selective Bromination of 4-Chloro-1-indanone and Synthesis of (4-Chloro-2, 3-Dihydro-1H-indene-2-yl)methanamine

被引：0

作者：

Jasouri, S. ^{[1
,2
]}

Khalafy, J. ^{[1
]}

Badali, M. ^{[2
]}

Piltan, M. ^{[1
]}

机构：

[1] Urmia Univ, Dept Chem, Orumiyeh 57154, Iran

[2] Daana Pharmaceut Co, Tabriz, Iran

来源：

SOUTH AFRICAN JOURNAL OF CHEMISTRY-SUID-AFRIKAANSE TYDSKRIF VIR CHEMIE | 2010年 / 63卷

关键词：

Indanone; bromination; cyanation; reduction; GABA(B) receptors; ALLOSTERIC MODULATORS; BIOLOGICAL-ACTIVITY; GABA(B) RECEPTORS; DERIVATIVES; 1-INDANONES; KETONES; WATER; ACID;

D O I：

暂无

中图分类号：

O6 [化学];

学科分类号：

0703 ;

摘要：

The synthesis of 4-chloro-1-indanone in four steps from 2-chlorobenzaldehyde was investigated. Bromination of this compound under various conditions occurred in the cyclopentanone ring, producing mono- and dibromo derivatives. Cyanation of 2-bromo-4-chloro-1-indanone followed by reduction gave (4-chloro-2, 3-dihydro-1H-indene-2-yl)methanamine in quantitative yield.

引用

页码：83 / 87

页数：5

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