Analysis of macrolide antibiotics

被引:152
作者
Kanfer, I [1 ]
Skinner, MF [1 ]
Walker, RB [1 ]
机构
[1] Rhodes Univ, Sch Pharmaceut Sci, ZA-6140 Grahamstown, South Africa
关键词
reviews; pharmaceutical analysis; antibiotics; macrolides; erythromycins;
D O I
10.1016/S0021-9673(98)00276-3
中图分类号
Q5 [生物化学];
学科分类号
071010 ; 081704 ;
摘要
The following macrolide antibiotics have been covered in this review: erythromycin and its related substances, azithromycin, clarithromycin, dirithromycin, roxithromycin, flurithromycin, josamycin, rokitamycin, kitasamycin, mycinamycin, mirosamycin, oleandomycin, rosaramicin, spiramycin and tylosin. The application of various thin-layer chromatography, paper chromatography, gas chromatography, high-performance liquid chromatography and capillary zone electrophoresis procedures for their analysis are described. These techniques have been applied to the separation and quantitative analysis of the macrolides in fermentation media, purity assessment of raw materials, assay of pharmaceutical dosage forms and the measurement of clinically useful macrolide antibiotics in biological samples such as blood, plasma, serum, urine and tissues. Data relating to the chromatographic behaviour of some macrolide antibiotics as well as the various detection methods used, such as bioautography, UV spectrophotometry, fluorometry, electrochemical detection, chemiluminescence and mass spectrometry techniques are also included. (C) 1998 Elsevier Science B.V. All rights reserved.
引用
收藏
页码:255 / 286
页数:32
相关论文
共 140 条
[1]   THIN-LAYER CHROMATOGRAPHY OF ERYTHROMYCINS [J].
ANDERSON, TT .
JOURNAL OF CHROMATOGRAPHY, 1964, 14 (01) :127-&
[2]   BIOSYNTHESIS OF THE MACROLIDE ANTIBIOTIC TYLOSIN - A PREFERRED PATHWAY FROM TYLACTONE TO TYLOSIN [J].
BALTZ, RH ;
SENO, ET ;
STONESIFER, J ;
WILD, GM .
JOURNAL OF ANTIBIOTICS, 1983, 36 (02) :131-141
[3]   THIN-LAYER AND COLUMN CHROMATOGRAPHY OF ERYTHROMYCINS AND SOME DEGRADATION PRODUCTS [J].
BANASZEK, A ;
KROWICKI, K ;
ZAMOJSKI, A .
JOURNAL OF CHROMATOGRAPHY, 1968, 32 (03) :581-&
[4]   SEPARATION AND DETERMINATION OF COMPONENTS OF SPIRAMYCIN IN BULK POWDERS AND IN PHARMACEUTICAL PREPARATIONS BY HIGH-PERFORMANCE LIQUID-CHROMATOGRAPHY [J].
BENS, GA ;
VANDENBOSSCHE, W ;
DEMOERLOOSE, P .
CHROMATOGRAPHIA, 1979, 12 (05) :294-298
[5]   APPLICATIONS OF A MODIFIED ISOHYDRIC SOLVENT SYSTEM IN HPLC ON SILICA-GEL FOR THE ANALYSIS OF THE MACROLIDE ANTIBIOTICS TURIMYCINS AND SPIRAMYCINS [J].
BENS, GA ;
CROMBEZ, E ;
DEMOERLOOSE, P .
JOURNAL OF LIQUID CHROMATOGRAPHY, 1982, 5 (08) :1449-1465
[6]   HIGH-PRESSURE LIQUID-CHROMATOGRAPHY OF MACROLIDE ANTIBIOTIC TYLOSIN [J].
BHUWAPATHANAPUN, S ;
GRAY, P .
JOURNAL OF ANTIBIOTICS, 1977, 30 (08) :673-674
[7]   SINGLE ORAL DOSE PHARMACOKINETICS OF ERYTHROMYCIN AND ROXITHROMYCIN AND THE EFFECTS OF CHRONIC DOSING [J].
BIRKETT, DJ ;
ROBSON, RA ;
GRGURINOVICH, N ;
TONKIN, A .
THERAPEUTIC DRUG MONITORING, 1990, 12 (01) :65-71
[8]  
BORNER K, 1992, METH SURV A, V22, P137
[9]   IDENTIFICATION OF ANTIBIOTIC RESIDUES IN MILK BY THIN-LAYER CHROMATOGRAPHY [J].
BOSSUYT, R ;
VANRENTERGHEM, R ;
WAES, G .
JOURNAL OF CHROMATOGRAPHY, 1976, 124 (01) :37-42
[10]   ISOLATION OF ERYTHROMYCIN-E FROM COMMERCIAL ERYTHROMYCIN [J].
CACHET, T ;
HAEST, G ;
BUSSON, R ;
JANSSEN, G ;
HOOGMARTENS, J .
JOURNAL OF CHROMATOGRAPHY, 1988, 445 (01) :290-294