Total synthesis of (+)-leucascandrolide A

被引：54

作者：

Su, QB

Panek, JS

机构：

[1] Boston Univ, Dept Chem, Boston, MA 02215 USA

[2] Boston Univ, Ctr Chem Methodol & Lib Dev, Boston, MA 02215 USA

来源：

ANGEWANDTE CHEMIE-INTERNATIONAL EDITION | 2005年 / 44卷 / 08期

关键词：

allylsilanes; annulation; antitumor agents; asymmetric synthesis; natural products;

D O I：

10.1002/anie.200462408

中图分类号：

O6 [化学];

学科分类号：

0703 ;

摘要：

A convergent and enantioselective total synthesis of (+)-leucascandrolide (1) was accomplished in 17 steps. Central to this synthesis is the rapid and efficient integration of the bispyran moiety into 1 using two consecutive [4 + 2] annulation reactions between an aldehyde and the chiral silanes 2 and 3 (TMS = trimethylsilyl, Mes = mesityl = 2,4,6-trimethylphenyl). © 2005 Wiley-VCH Verlag GmbH & Co. KGaA, Weinheim.

引用

页码：1223 / 1225

页数：3

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