Transition-Metal-Free, Potassium tert-Butoxide/Dimethyl Sulfoxide Mediated Amination between Tertiary Amines and Aryl Halides

被引：14

作者：

Huang, Pei ^{[1
]}

He, Bang-Yue ^{[1
]}

Wang, Hui-Min ^{[1
]}

Lu, Jian-Mei ^{[1
]}

机构：

[1] Wenzhou Univ, Coll Chem & Mat Engn, Wenzhou 325035, Zhejiang, Peoples R China

来源：

SYNTHESIS-STUTTGART | 2015年 / 47卷 / 02期

关键词：

transition-metal-free; tertiary amines; aryl halides; amination reaction; synthetic method; CROSS-COUPLING REACTIONS; FACILE N-ARYLATION; CATALYZED AMINATION; DIARYLIODONIUM SALTS; CARBON-CARBON; CHLORIDES; ARYNES; COMPLEXES; CHEMISTRY; LIGANDS;

D O I：

10.1055/s-0034-1379367

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

A transition-metal-free, C-N bond-formation reaction between tertiary amines and aryl halides is reported. Under the optimal conditions, various aromatic and aliphatic tertiary amines react with aryl halides, including iodides, bromides, and chlorides, to give mono-aminated products, N,N-dialkylanilines and N-alkyl-N-arylanilines, in good to high yields. Based on the experimental results, the reaction is believed to occur via an aryne intermediate derived from the aryl halide.

引用

页码：221 / 227

页数：7

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