Cancer - Out of air is not out of action

被引:130
作者
Bottaro, DP [1 ]
Liotta, LA
机构
[1] NCI, Urol Oncol Branch, NIH, Bethesda, MD 20892 USA
[2] NCI, Invas & Metastasis Sect, Pathol Lab, NIH, Bethesda, MD 20892 USA
关键词
D O I
10.1038/423593a
中图分类号
O [数理科学和化学]; P [天文学、地球科学]; Q [生物科学]; N [自然科学总论];
学科分类号
07 ; 0710 ; 09 ;
摘要
Starving cancers of oxygen would seem to be a good way of killing them, but the presence of oxygen-deprived areas in tumours appears to correlate with poor prognosis. A molecular explanation for this has now been found.
引用
收藏
页码:593 / 595
页数:3
相关论文
共 14 条
[1]  
Bardelli A, 1997, CIBA F SYMP, V212, P133
[2]   Developmental roles of HGF/SF and its receptor, the c-Met tyrosine kinase [J].
Birchmeier, C ;
Gherardi, E .
TRENDS IN CELL BIOLOGY, 1998, 8 (10) :404-410
[3]  
Birchmeier W, 1997, CIBA F SYMP, V212, P230
[4]   Role of vascular endothelial growth factor in Physiologic and Pathologic angiogenesis: Therapeutic implications [J].
Ferrara, N .
SEMINARS IN ONCOLOGY, 2002, 29 (06) :10-14
[5]   Hepatocyte growth factor: from diagnosis to clinical applications [J].
Funakoshi, H ;
Nakamura, T .
CLINICA CHIMICA ACTA, 2003, 327 (1-2) :1-23
[6]   Biological consequences of tumor hypoxia [J].
Höckel, M ;
Vaupel, P .
SEMINARS IN ONCOLOGY, 2001, 28 (02) :36-41
[7]   Tumor angiogenesis and accessibility: Role of vascular endothelial growth factor [J].
Jain, RK .
SEMINARS IN ONCOLOGY, 2002, 29 (06) :3-9
[8]   Activating mutations for the Met tyrosine kinase receptor in human cancer [J].
Jeffers, M ;
Schmidt, L ;
Nakaigawa, N ;
Webb, CP ;
Weirich, G ;
Kishida, T ;
Zbar, B ;
VandeWoude, GF .
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 1997, 94 (21) :11445-11450
[9]   The contribution of VHL substrate binding and HIF1-α to the phenotype of VHL loss in renal cell carcinoma [J].
Maranchie, JK ;
Vasselli, JR ;
Riss, J ;
Bonifacino, JS ;
Linehan, WM ;
Klausner, RD .
CANCER CELL, 2002, 1 (03) :247-255
[10]   Liver regeneration [J].
Michalopoulos, GK ;
DeFrances, MC .
SCIENCE, 1997, 276 (5309) :60-66