The Drosophila calcineurin regulator, Sarah, is involved in male courtship

被引：3

作者：

Sakai, Takaomi ^{[1
]}

Aigaki, Toshiro ^{[1
]}

机构：

[1] Tokyo Metropolitan Univ, Dept Biol Sci, Tokyo 1920397, Japan

来源：

NEUROREPORT | 2010年 / 21卷 / 15期

关键词：

courtship behavior; Drosophila; mushroom bodies; Sarah; SYNDROME CRITICAL REGION; MUSHROOM BODIES; MELANOGASTER; HOMOLOG; EXPRESSION; BEHAVIOR;

D O I：

10.1097/WNR.0b013e32833eaade

中图分类号：

Q189 [神经科学];

学科分类号：

071006 ;

摘要：

The Drosophila Sarah (sra) gene encodes a regulator of the Ca(2+)/calmodulin-dependent protein phosphatase, calcineurin, and plays an essential role in various biological processes. Here, we describe a novel role of sra in Drosophila male courtship behavior. sra null mutant males have reduced courtship activity. This reduced activity can be rescued by expressing sra in the mushroom bodies (MBs), brain structures important for memory formation and storage in Drosophila. In addition, overexpressing sra in the MBs, and transiently overexpressing sra during adulthood, inhibits male courtship. Our results indicate that a specific amount of sra in the MBs is required for wildtype male courtship activity. NeuroReport 21:985-988 (C) 2010 Wolters Kluwer Health vertical bar Lippincott Williams & Wilkins.

引用

页码：985 / 988

页数：4

共 12 条

[1] Centrophobism/thigmotaxis, a new role for the mushroom bodies in Drosophila
Besson, M
Martin, JR
[J]. JOURNAL OF NEUROBIOLOGY, 2005, 62 (03): : 386 - 396
[2] BRAND AH, 1993, DEVELOPMENT, V118, P401
[3] Drosophila melanogaster homolog of Down syndrome critical region 1 is critical for mitochondrial function
Chang, KT
Min, KT
[J]. NATURE NEUROSCIENCE, 2005, 8 (11) : 1577 - 1585
[4] The Drosophila homolog of Down's syndrome critical region 1 gene regulates learning:: Implications for mental retardation
Chang, KT
Shi, YJ
Min, KT
[J]. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 2003, 100 (26) : 15794 - 15799
[5] Expression level of sarah, a Homolog of DSCR1, is critical for ovulation and female courtship behavior in Drosophila melanogaster
Ejima, A
Tsuda, M
Takeo, S
Ishii, K
Matsuo, T
Aigaki, T
[J]. GENETICS, 2004, 168 (04) : 2077 - 2087
[6] The RCN family of calcineurin regulators
Hilioti, Z
Cunningham, KW
[J]. BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS, 2003, 311 (04) : 1089 - 1093
[7] The Drosophila calcipressin sarah is required for several aspects of egg activation
Horner, Vanessa L.
Czank, Andreas
Jang, Janet K.
Singh, Navjot
Williams, Byron C.
Puro, Jaakko
Kubli, Eric
Hanes, Steven D.
McKim, Kim S.
Wolfner, Mariana F.
Goldberg, Michael L.
[J]. CURRENT BIOLOGY, 2006, 16 (14) : 1441 - 1446
[8] Martin JR, 1998, LEARN MEMORY, V5, P179
[9] A protein encoded within the Down syndrome critical region is enriched in striated muscles and inhibits calcineurin signaling
Rothermel, B
Vega, RB
Yang, J
Wu, H
Bassel-Duby, R
Williams, RS
[J]. JOURNAL OF BIOLOGICAL CHEMISTRY, 2000, 275 (12) : 8719 - 8725
[10] The Drosophila TRPA channel, Painless, regulates sexual receptivity in virgin females
Sakai, T.
Kasuya, J.
Kitamoto, T.
Aigaki, T.
[J]. GENES BRAIN AND BEHAVIOR, 2009, 8 (05) : 546 - 557

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