Hyperactivated RAGE in Comorbidities as a Risk Factor for Severe COVID-19-The Role of RAGE-RAS Crosstalk

被引：21
作者：
Chiappalupi, Sara [1 ,2 ]
Salvadori, Laura [2 ,3 ]
Donato, Rosario [2 ]
Riuzzi, Francesca [1 ,2 ,4 ]
Sorci, Guglielmo [1 ,2 ,4 ,5 ]
机构：
[1] Univ Perugia, Dept Med & Surg, I-06132 Perugia, Italy
[2] Interuniv Inst Myol IIM, I-06132 Perugia, Italy
[3] Univ Piemonte Orientale, Dept Translat Med, I-28100 Novara, Italy
[4] Consorzio Interuniv Biotecnol CIB, I-34127 Trieste, Italy
[5] Univ Perugia, Ctr Univ Ric Genom Funz CURGeF, I-06132 Perugia, Italy
来源：
BIOMOLECULES | 2021年 / 11卷 / 06期
关键词：
COVID-19; comorbidities; RAGE; AGER polymorphisms; GLYCATION END-PRODUCTS; ENDOGENOUS SECRETORY RECEPTOR; RENIN-ANGIOTENSIN SYSTEM; MOBILITY GROUP BOX-1; SOLUBLE RECEPTOR; ENDPRODUCTS RAGE; OXIDATIVE STRESS; SERUM-LEVELS; KAPPA-B; DISEASE;
D O I：
10.3390/biom11060876
中图分类号：
Q5 [生物化学]; Q7 [分子生物学];
学科分类号：
071010 ; 081704 ;
摘要：
The receptor for advanced glycation-end products (RAGE) is a multiligand receptor with a role in inflammatory and pulmonary pathologies. Hyperactivation of RAGE by its ligands has been reported to sustain inflammation and oxidative stress in common comorbidities of severe COVID-19. RAGE is essential to the deleterious effects of the renin-angiotensin system (RAS), which participates in infection and multiorgan injury in COVID-19 patients. Thus, RAGE might be a major player in severe COVID-19, and appears to be a useful therapeutic molecular target in infections by SARS-CoV-2. The role of RAGE gene polymorphisms in predisposing patients to severe COVID-19 is discussed.
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页数：23
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