Developments in the Pathology of Penile Squamous Cell Carcinomas

被引:30
作者
Chaux, Alcides
Velazquez, Elsa F.
Algaba, Ferran
Ayala, Gustavo
Cubilla, Antonio L. [1 ]
机构
[1] Inst Patol & Invest, Asuncion, Paraguay
关键词
HUMAN-PAPILLOMAVIRUS DNA; LYMPH-NODE METASTASIS; CLINICOPATHOLOGICAL FEATURES; ADENOSQUAMOUS CARCINOMA; UNITED-STATES; RISK-FACTORS; HISTOLOGIC GRADE; CANCER; CLASSIFICATION; WARTY;
D O I
10.1016/j.urology.2010.02.038
中图分类号
R5 [内科学]; R69 [泌尿科学(泌尿生殖系疾病)];
学科分类号
1002 ; 100201 ;
摘要
Most penile cancers are squamous cell carcinoma (SCC) originating in the epithelium covering glans, coronal sulcus, and foreskin. Several histologic subtypes have been described, each with distinctive clinicopathologic and outcome features. The most common subtype is the usual SCC, representing one half to two thirds of penile carcinomas. Penile verruciform tumors encompass verrucous, warty (condylomatous), and papillary, not otherwise specified, carcinomas. As a group, verruciform tumors are low grade, with low metastatic and mortality rates. In contrast, basaloid and sarcomatoid carcinomas are among the most aggressive penile tumors. Other SCC variants, such as carcinoma cuniculatum and pseudohyperplastic, adenosquamous and acantholytic carcinomas, are rare. The most relevant clinicopathologic and outcome features are outlined for each of these SCC subtypes, and an algorithm that might aid the pathologist in the histologic classification is presented. In addition, recommendations for handling penile cancer specimens, frozen section specimens, and pathology reports are provided. UROLOGY 76 (Suppl 2A): S7-S14, 2010. (C) 2010 Elsevier Inc.
引用
收藏
页码:S7 / S14
页数:8
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