Effect of epimedium decoction on hemorheology and bone tissue of rabbit steroid induced necrosis of femoral head

被引:0
作者
Meng, Dongfang [1 ]
Li, Huiying [1 ]
Wang, Lihe [1 ]
Song, Xiaolei [1 ]
Zhang, Xiaorui [1 ]
机构
[1] Henan Univ Tradit Chinese Med, Affiliated Hosp 1, Dept Orthoped & Traumatol, 19 Renmin Rd, Zhengzhou 450000, Henan, Peoples R China
来源
INTERNATIONAL JOURNAL OF CLINICAL AND EXPERIMENTAL MEDICINE | 2017年 / 10卷 / 10期
关键词
Osteonecrosis of the femoral head (ONFH); bone mineral density; epimedium; hemorheology; INDUCED OSTEONECROSIS; EXTRACT; RATS;
D O I
暂无
中图分类号
R-3 [医学研究方法]; R3 [基础医学];
学科分类号
1001 ;
摘要
Objectives: This study is to research the effect of epimedium decoction on hemorheology, bone mineral density and osteocyte of steroid induced necrosis of femoral head (SONFH). Methods: After establishing the model of SONFH the treatment group was given 10 ml epimedium decoction by gavage. After eight weeks of that, we detected the hemorheology, bone mineral density and osteocyte of rabbits in treatment group, model group and blank group, and made comparison among groups. Results: The results of hemorheology showed that blood viscosity in treatment group was reduced compared with model group. There was a significant difference between the plasma viscosity in treatment group and in model group (P = 0.017 < 0.05). The hematocrit in treatment group was significantly lower than model group (P = 1.21x10(-4) < 0.05). Bone mineral density in treatment group was greatly increased compared with model group (P = 1.26x10(-5) < 0.05) and without significant difference with blank group. The pathological section indicated that in treatment group most osteocytes in bone trabecula within the femoral head were normal with regular arrangement and visible osteoblast and osteoclast, which was different with model group. And the amount of various hematopoietic cells in cavum medullarein treatment group was increased compared with model group. Conclusion: Epimedium decoction could improve the hemorheology of SONFH, promote the generation of osteoblast and the inhibition of osteoclast, increase bone mineral density, which were beneficial to the rapid repairing of bone tissue.
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页码:14940 / 14945
页数:6
相关论文
共 16 条
  • [1] Repair of Critical Calvarias Defects With Systemic Epimedium sagittatum Extract
    Burim, Rafael Augusto
    Sendyk, Daniel Isaac
    Hernandes, Leandro Santoro
    Martins de Souza, Daniel Falbo
    Correa, Luciana
    Zindel Deboni, Maria Cristina
    [J]. JOURNAL OF CRANIOFACIAL SURGERY, 2016, 27 (03) : 799 - 804
  • [2] Nationwide Epidemiologic Survey of Idiopathic Osteonecrosis of the Femoral Head
    Fukushima, Wakaba
    Fujioka, Mikihiro
    Kubo, Toshikazu
    Tamakoshi, Akiko
    Nagai, Masaki
    Hirota, Yoshio
    [J]. CLINICAL ORTHOPAEDICS AND RELATED RESEARCH, 2010, 468 (10) : 2715 - 2724
  • [3] Herb-Drug Interaction of Epimedium sagittatum (Sieb. et Zucc.) Maxim Extract on the Pharmacokinetics of Sildenafil in Rats
    Hsueh, Thomas Y.
    Wu, Yu-Tse
    Lin, Lie-Chwen
    Chiu, Allen W.
    Lin, Chi-Hung
    Tsai, Tung-Hu
    [J]. MOLECULES, 2013, 18 (06) : 7323 - 7335
  • [4] Risk period for developing osteonecrosis of the femoral head in patients on steroid treatment
    Koo, KH
    Kim, R
    Kim, YS
    Ahn, IO
    Cho, SH
    Song, HR
    Park, YS
    Kim, H
    Wang, GJ
    [J]. CLINICAL RHEUMATOLOGY, 2002, 21 (04) : 299 - 303
  • [5] Clinical and basic research on steroid-induced osteonecrosis of the femoral head in Japan
    Kubo, Toshikazu
    Ueshima, Keiichiro
    Saito, Masazumi
    Ishida, Masashi
    Arai, Yuji
    Fujiwara, Hiroyoshi
    [J]. JOURNAL OF ORTHOPAEDIC SCIENCE, 2016, 21 (04) : 407 - 413
  • [6] Lavernia C J, 1999, J Am Acad Orthop Surg, V7, P250
  • [7] Li CG, 2016, CHIN J INTEGR MED
  • [8] Liu Wen-Gang, 2012, Zhongguo Gu Shang, V25, P407
  • [9] Biomarkers and pharmaceutical strategies in steroid-induced osteonecrosis of the femoral head: A literature review
    Qi, Xinyu
    Zeng, Yirong
    [J]. JOURNAL OF INTERNATIONAL MEDICAL RESEARCH, 2015, 43 (01) : 3 - 8
  • [10] Wang Jian-zhong, 2011, Nan Fang Yi Ke Da Xue Xue Bao, V31, P1714