Frizzled 8 promotes the cell proliferation and metastasis of renal cell carcinoma

被引：20
|
作者：
Yang, Qiwei [1 ,2 ]
Wang, Ye [3 ]
Pan, Xiuwu [1 ,2 ]
Ye, Jianqing [1 ]
Gan, Sishun [1 ]
Qu, Fajun [1 ]
Chen, Lu [4 ]
Chu, Chuanmin [1 ]
Gao, Yi [4 ]
Cui, Xingang [1 ]
机构：
[1] Second Mil Med Univ, Affiliated Hosp 3, Dept Urol, Eastern Hepatobiliary Surg Hosp, Shanghai 201805, Peoples R China
[2] Second Mil Med Univ, Changzheng Hosp, Dept Urol, Shanghai 200003, Peoples R China
[3] Second Mil Med Univ, Changhai Hosp, Dept Urol, Shanghai 200082, Peoples R China
[4] Shanghai Jiao Tong Univ, Ruijin Hosp, Dept Urol, Shanghai 200025, Peoples R China
来源：
ONCOTARGET | 2017年 / 8卷 / 45期
基金：
中国国家自然科学基金;
关键词：
renal cell carcinoma; Wnt/beta-catenin; Frizzled; 8; proliferation; metastasis; EPITHELIAL-MESENCHYMAL TRANSITION; UNFAVORABLE PROGNOSIS; OVARIAN-CANCER; UP-REGULATION; WNT; MIGRATION; EXPRESSION; ROR2; TUMORIGENESIS; RECEPTORS;
D O I：
10.18632/oncotarget.20742
中图分类号：
R73 [肿瘤学];
学科分类号：
100214 ;
摘要：
Recent reports have shown a rapid rise in the incidence of renal cell carcinoma (RCC), and Wnt (Wingless-related integration site) signaling pathway is important in RCC. Frizzled 8 (FZD8) is a member of Frizzled (FZD) receptor family which could activate canonical or non-canonical Wnt/beta-catenin pathways. Nevertheless, the role of FZD8 in RCC is poorly investigated. The immunohistochemical analysis showed high expression of FZD8 in RCC tissues compared with peri-tumor tissues. FZD8 knockdown decreased the ability of proliferation and metastasis of RCC cells. Research revealed that the FZD8 regulated the transcription of Cyclin D1, c-Myc, and could promote the epithelial to mesenchymal transition (EMT) by mediating Vimentin and Snail through the Wnt/beta-catenin signaling pathway. In addition, the results of our experiment revealed that FZD8 is involved in the regulation of non-canonical Wnt signaling pathway. These data suggested that the expression of FZD8 may play an important role in the proliferation and metastasis of RCC, and serve as a putative promising drug target for human RCC therapy.
引用
收藏
页码：78989 / 79002
页数：14
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