Technology Insight: biomarker development in acute kidney injury - what can we anticipate?

被引：43

作者：

Molitoris, Bruce A. ^{[1
,2
]}

Melnikov, Vyacheslav Y. ^{[3
]}

Okusa, Mark D. ^{[4
,5
]}

Hirnmelfarb, Jonathan ^{[6
]}

机构：

[1] Indiana Univ, Sch Med, Div Nephrol, Indianapolis, IN 46202 USA

[2] Indiana Univ, Sch Med, Div Nephrol, Dept Med, Indianapolis, IN 46202 USA

[3] Indiana Univ, Sch Med, Indiana Ctr Biol Microsocp, Indianapolis, IN 46202 USA

[4] Univ Virginia, Dept Med, Ctr Immunity Inflammat & Regenerat Med, Charlottesville, VA USA

[5] Univ Virginia, Div Nephrol, Charlottesville, VA USA

[6] Main Med Ctr, Ctr Clin & Translat Res, Dept Med, Div Nephrol, Portland, ME USA

来源：

NATURE CLINICAL PRACTICE NEPHROLOGY | 2008年 / 4卷 / 03期

关键词：

acute renal failure; acute tubular necrosis; glomerular filtration rate; prerenal azotemia; renal function;

D O I：

10.1038/ncpneph0723

中图分类号：

R5 [内科学]; R69 [泌尿科学（泌尿生殖系疾病）];

学科分类号：

1002 ; 100201 ;

摘要：

Early diagnosis has been the 'Achilles heel' of acute kidney injury (AKI) that has prevented successful implementation of treatment strategies. To date, pharmacological intervention has been largely unsuccessful or equivocal, and morbidity and mortality associated with AKI have remained unacceptably high. Despite their well-known limitations, the most widely used biomarkers for the early diagnosis of AKI are serum creatinine, blood urea nitrogen and urine output. Development of new biomarkers is imperative. A variety of methods have been employed of discover new biomarkers of AKI, including transcriptomics, proteomics, gene arrays, lipidomics and imaging technologies. Clinical trials are undersay to establish the validity of the biomarkers discovered using these techniques. This Review summarizes the importance of biomarkers of AKI, from their discovery to clinical practice, from the current perspective and that of what to expect in the future. Great strides forward are being made in breaking down important barriers to the successful prevention and treatment of this devastating disorder.

引用

页码：154 / 165

页数：12

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