Ultrasound-mediated interferon β gene transfection inhibits growth of malignant melanoma

被引：18

作者：

Yamaguchi, Kazuki ^{[1
,2
]}

Feril, Loreto B., Jr. ^{[1
]}

Tachibana, Katsuro ^{[1
]}

Takahashi, Akira ^{[2
]}

Matsuo, Miki ^{[2
]}

Endo, Hitomi ^{[2
]}

Harada, Yoshimi ^{[1
]}

Nakayama, Juichiro ^{[2
]}

机构：

[1] Fukuoka Univ, Sch Med, Dept Anat, Jonan Ku, Fukuoka 8140180, Japan

[2] Fukuoka Univ, Sch Med, Dept Dermatol, Jonan Ku, Fukuoka 8140180, Japan

来源：

BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS | 2011年 / 411卷 / 01期

关键词：

Ultrasound; Sonotransfection; Melanoma; Interferon beta; PLASMID DNA; THERAPY; SONOPORATION; ENHANCEMENT; EXPRESSION; INDUCTION; EFFICIENT; DELIVERY; MUSCLE; CELLS;

D O I：

10.1016/j.bbrc.2011.06.115

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

We investigated the effects of ultrasound-mediated transfection (sonotransfection) of interferon beta (IFN-beta) gene on melanoma (C32) both in vitro and in vivo. C32 cells were sonotransfected with IFN-beta in vitro. Subcutaneous C32 tumors in mice were sonicated weekly immediately after intra-tumor injection with IFN-beta genes mixed with microbubbles. Successful sonotransfection with IFN-beta gene in vitro was confirmed by ELISA, which resulted in C32 growth inhibition. In vivo, the growth ratio of tumors transfected with IFN-beta gene was significantly lower than the other experimental groups. These results may lead to a new method of treatment against melanoma and other hard-to-treat cancers. (C) 2011 Elsevier Inc. All rights reserved.

引用

页码：137 / 142

页数：6

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