Ultrasound-mediated interferon β gene transfection inhibits growth of malignant melanoma

被引：18
|
作者：
Yamaguchi, Kazuki [1 ,2 ]
Feril, Loreto B., Jr. [1 ]
Tachibana, Katsuro [1 ]
Takahashi, Akira [2 ]
Matsuo, Miki [2 ]
Endo, Hitomi [2 ]
Harada, Yoshimi [1 ]
Nakayama, Juichiro [2 ]
机构：
[1] Fukuoka Univ, Sch Med, Dept Anat, Jonan Ku, Fukuoka 8140180, Japan
[2] Fukuoka Univ, Sch Med, Dept Dermatol, Jonan Ku, Fukuoka 8140180, Japan
来源：
BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS | 2011年 / 411卷 / 01期
关键词：
Ultrasound; Sonotransfection; Melanoma; Interferon beta; PLASMID DNA; THERAPY; SONOPORATION; ENHANCEMENT; EXPRESSION; INDUCTION; EFFICIENT; DELIVERY; MUSCLE; CELLS;
D O I：
10.1016/j.bbrc.2011.06.115
中图分类号：
Q5 [生物化学]; Q7 [分子生物学];
学科分类号：
071010 ; 081704 ;
摘要：
We investigated the effects of ultrasound-mediated transfection (sonotransfection) of interferon beta (IFN-beta) gene on melanoma (C32) both in vitro and in vivo. C32 cells were sonotransfected with IFN-beta in vitro. Subcutaneous C32 tumors in mice were sonicated weekly immediately after intra-tumor injection with IFN-beta genes mixed with microbubbles. Successful sonotransfection with IFN-beta gene in vitro was confirmed by ELISA, which resulted in C32 growth inhibition. In vivo, the growth ratio of tumors transfected with IFN-beta gene was significantly lower than the other experimental groups. These results may lead to a new method of treatment against melanoma and other hard-to-treat cancers. (C) 2011 Elsevier Inc. All rights reserved.
引用
收藏
页码：137 / 142
页数：6
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