Pathways of polyunsaturated fatty acid utilization: Implications for brain function in neuropsychiatric health and disease

被引：163

作者：

Liu, Joanne J. ^{[1
,2
]}

Green, Pnina ^{[3
]}

Mann, J. John ^{[1
,4
,5
]}

Rapoport, Stanley I. ^{[6
]}

Sublette, M. Elizabeth ^{[1
,4
]}

机构：

[1] New York State Psychiat Inst & Hosp, Dept Mol Imaging & Neuropathol, New York, NY 10032 USA

[2] New York Med Coll, Valhalla, NY 10595 USA

[3] Tel Aviv Univ, Felsenstein Med Res Ctr, Lab Metab Res, Petah Tiqwa, Israel

[4] Columbia Univ, Dept Psychiat, New York, NY USA

[5] Columbia Univ, Dept Radiol, New York, NY USA

[6] NIA, Brain Physiol & Metab Sect, Neurosci Lab, NIH, Bethesda, MD 20892 USA

来源：

BRAIN RESEARCH | 2015年 / 1597卷

关键词：

Polyunsaturated fatty acids; Lipid metabolism; Brain; Depression; Bipolar disorder; Schizophrenia; ALPHA-LINOLENIC ACID; OMEGA-3-FATTY-ACID DOCOSAHEXAENOIC ACID; PROLIFERATOR-ACTIVATED RECEPTORS; LONG-CHAIN OMEGA-3-FATTY-ACIDS; LOW-DENSITY LIPOPROTEINS; DEFICIT-HYPERACTIVITY-DISORDER; CAPILLARY ENDOTHELIAL-CELLS; ADENYLATE-CYCLASE ACTIVITY; MAJOR DEPRESSIVE DISORDER; SOLUBLE BINDING-PROTEINS;

D O I：

10.1016/j.brainres.2014.11.059

中图分类号：

Q189 [神经科学];

学科分类号：

071006 ;

摘要：

Essential polyunsaturated fatty acids (PUPAS) have profound effects on brain development and function. Abnormalities of PUPA status have been implicated in neuropsychiatric diseases such as major depression, bipolar disorder, schizophrenia, Alzheimer's disease, and attention deficit hyperactivity disorder. Pathophysiologic mechanisms could involve not only suboptimal PUPA intake, but also metabolic and genetic abnormalities, defective hepatic metabolism, and problems with diffusion and transport. This article provides an overview of physiologic factors regulating PUPA utilization, highlighting their relevance to neuropsychiatric disease. (C) 2014 Elsevier B.V. All rights reserved.

引用

页码：220 / 246

页数：27

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