The Role of Sex and Sex Hormones in Regulating Obesity-Induced Inflammation

被引：47

作者：

Varghese, Mita ^{[1
]}

Griffin, Cameron ^{[1
]}

Singer, Kanakadurga ^{[1
]}

机构：

[1] Univ Michigan, Div Pediat Endocrinol, Dept Pediat & Communicable Dis, Ann Arbor, MI 48109 USA

来源：

SEX AND GENDER FACTORS AFFECTING METABOLIC HOMEOSTASIS, DIABETES AND OBESITY | 2017年 / 1043卷

关键词：

TUMOR-NECROSIS-FACTOR; HIGH-FAT-DIET; ADIPOSE-TISSUE MACROPHAGES; NITRIC-OXIDE SYNTHASE; BODY-MASS INDEX; FACTOR-ALPHA; INSULIN-RESISTANCE; GENDER-DIFFERENCES; ANDROGEN RECEPTOR; METABOLIC COMPLICATIONS;

D O I：

10.1007/978-3-319-70178-3_5

中图分类号：

Q5 [生物化学];

学科分类号：

071010 ; 081704 ;

摘要：

Metabolic and non-metabolic complications due to obesity are becoming more prevalent, yet our understanding of the mechanisms driving these is not. This is due to individual risk factor variability making it difficult to predict disease outcomes such as diabetes and insulin resistance. Gender is a critical factor in obesity outcomes with women having more adiposity but reduced metabolic complications compared to men. The role of immune system activation during obesity is an emerging field that links adiposity to metabolic syndrome. Furthermore, evidence from animal models suggests that sex differences exist in immune responses and, therefore, could be a possible mechanism leading to sex differences in metabolic disease. While there is still much to learn in the area of sex-differences research, this chapter will review the current knowledge and literature detailing the role of sex and sex hormones on adiposity and metabolically induced inflammation in obesity.

引用

页码：65 / 86

页数：22

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