Metabolic Profile in Early Pregnancy Is Associated with Offspring Adiposity at 4 Years of Age: The Rhea Pregnancy Cohort Crete, Greece

被引：64

作者：

Daraki, Vasiliki ^{[1
,2
]}

Georgiou, Vaggelis ^{[1
]}

Papavasiliou, Stathis ^{[2
]}

Chalkiadaki, Georgia ^{[1
]}

Karahaliou, Marianna ^{[1
]}

Koinaki, Stella ^{[1
]}

Sarri, Katerina ^{[1
]}

Vassilaki, Maria ^{[1
]}

Kogevinas, Manolis ^{[3
,4
,5
,6
]}

Chatzi, Leda ^{[1
]}

机构：

[1] Univ Crete, Fac Med, Dept Social Med, Iraklion, Greece

[2] Univ Hosp Crete, Clin Endocrinol, Iraklion, Greece

[3] Ctr Res Environm Epidemiol CREAL, Barcelona, Spain

[4] IMIM Hosp Mar Res Inst, Barcelona, Spain

[5] CIBERESP, Barcelona, Spain

[6] Natl Sch Publ Hlth, Athens, Greece

来源：

PLOS ONE | 2015年 / 10卷 / 05期

基金：

欧盟第七框架计划;

关键词：

GESTATIONAL WEIGHT-GAIN; MATERNAL OBESITY; RISK-FACTORS; PLACENTAL CONTRIBUTION; CHILDHOOD OBESITY; GENE-EXPRESSION; SEX-DIFFERENCES; CHILDREN; HEALTH; DISEASE;

D O I：

10.1371/journal.pone.0126327

中图分类号：

O [数理科学和化学]; P [天文学、地球科学]; Q [生物科学]; N [自然科学总论];

学科分类号：

07 ; 0710 ; 09 ;

摘要：

Context Maternal pre-pregnancy obesity may increase the risk of childhood obesity but it is unknown whether other metabolic factors in early pregnancy such as lipid profile and hypertension are associated with offspring cardiometabolic traits. Objective Our objective was to investigate whether fasting lipid, glucose, and insulin levels during early pregnancy and maternal pre-pregnancy weight status, are associated with offspring adiposity measures, lipid levels and blood pressure at preschool age. Design and Methods The study included 618 mother-child pairs of the pregnancy cohort "Rhea" study in Crete, Greece. Pregnant women were recruited at the first prenatal visit (mean: 12weeks, SD: 0.7). A subset of 348 women provided fasting serum samples for glucose and lipid measurements. Outcomes measures were body mass index, abdominal circumference, sum of skin-fold thickness, and blood pressure measurements at 4 years of age. A subsample of 525 children provided non-fasting blood samples for lipid measurements. Results Pre-pregnancy overweight/obesity was associated with greater risk of offspring overweight/ obesity (RR: 1.83, 95% CI: 1.19, 2.81), central adiposity (RR: 1.97, 95% CI: 1.11, 3.49), and greater fat mass by 5.10mm (95% CI: 2.49, 7.71) at 4 years of age. These associations were more pronounced in girls. An increase of 40mg/dl in fasting serum cholesterol levels in early pregnancy was associated with greater skinfold thickness by 3.30mm (95% CI: 1.41, 5.20) at 4 years of age after adjusting for pre-pregnancy BMI and several other confounders. An increase of 10mmHg in diastolic blood pressure in early pregnancy was associated with increased risk of offspring overweight/obesity (RR: 1.22, 95% CI: 1.03, 1.45), and greater skinfold thickness by 1.71mm (95% CI: 0.57, 2.86) at 4 years of age. Conclusions Metabolic dysregulation in early pregnancy may increase the risk of obesity at preschool age.

引用

页数：18

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