Sporothriolide-Related Compounds from the Fungus Hypoxylon monticulosum CLL-205 Isolated from a Sphaerocladina Sponge from the Tahiti Coast

被引：26

作者：

Leman-Loubiere, Charlotte ^{[1
]}

Le Goff, Geraldine ^{[1
]}

Retailleau, Pascal ^{[1
]}

Debitus, Cecile ^{[2
]}

Ouazzani, Jamal ^{[1
]}

机构：

[1] CNRS, ICSN, Ave Terrasse, F-91198 Gif Sur Yvette, France

[2] Univ Bretagne Occidentale, IFREMER, CNRS, LEMAR,IRD,IUEM, Technopole Brest Iroise,Rue Dumont dUrville, F-29280 Plouzane, France

来源：

JOURNAL OF NATURAL PRODUCTS | 2017年 / 80卷 / 10期

关键词：

HYALURONIDASE; 4-EPI-ETHISOLIDE; METABOLITES; ACID;

D O I：

10.1021/acs.jnatprod.7b00714

中图分类号：

Q94 [植物学];

学科分类号：

071001 ;

摘要：

Two sporothriolide-related compounds were obtained from an extract of the fungus Hypoxylon monticulosum CLL-205, isolated from a Sphaerocladina sponge collected from the Tahiti coast. Compound 2 is a deoxy analogue of sporothric acid (4). Compound 3 is a newly reported unusual scaffold combining sporothriolide (1) and trienylfuranol A (5) moieties, through a Diels-Alderase-type reaction. Various experimental and analytical arguments supported the biocatalytic origin of compound 3. The structures of the isolated compounds were elucidated using 1D and 2D NMR, HRMS, and IR data. The structure and the absolute configuration of 3 were unambiguously confirmed by a single-crystal X-ray diffraction analysis.

引用

页码：2850 / 2854

页数：5

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