Spread of GES-5 carbapenemase-producing Pseudomonas aeruginosa clinical isolates in Japan due to clonal expansion of ST235

被引：40
|
作者：
Hishinuma, Tomomi [1 ]
Tada, Tatsuya [1 ]
Kuwahara-Arai, Kyoko [1 ]
Yamamoto, Norio [1 ]
Shimojima, Masahiro [2 ]
Kirikae, Teruo [1 ]
机构：
[1] Juntendo Univ, Sch Med, Dept Microbiol, Tokyo, Japan
[2] BML Inc, Kawagoe, Saitama, Japan
来源：
PLOS ONE | 2018年 / 13卷 / 11期
基金：
日本学术振兴会;
关键词：
SPECTRUM BETA-LACTAMASE; BLUE-CARBA; ACINETOBACTER; EMERGENCE; OUTBREAK; SEQUENCE; STRAIN;
D O I：
10.1371/journal.pone.0207134
中图分类号：
O [数理科学和化学]; P [天文学、地球科学]; Q [生物科学]; N [自然科学总论];
学科分类号：
07 ; 0710 ; 09 ;
摘要：
The first outbreak in Japan of GES-5 carbapenemase-producing Pseudomonas aeruginosa occurred in a long-term care facility in 2014. To assess the spread of GES-5 producing P. aeruginosa clinical isolates in medical settings in Japan, 1,476 carbapenem-resistant P. aeruginosa isolates obtained from 2012 to 2016 were characterized. Of these 1,476 isolates, 104 (7.0%) harbored bla(GES-5). Southern blotting revealed that the bla(GES-5) was located on the chromosome. The isolation rates of these GES-5 producers increased significantly every year, from 2.0% (6 of 295) in 2012 to 2.8% (8 of 283) in 2013 to 5.3% (16 of 303) in 2014 to 9.7% (29 of 300) in 2015 to 15.3% (45 of 295) in 2016. Of the 104 GES-5 producers, 102 belonged to clonal complex (CC) 235, including 99 belonging to ST235 and three belonging to ST2233). Whole genome sequence analysis revealed that CC235 P. aeruginosa harboring bla(GES-5) spread in a clonal manner. These results indicate that these GES-5 producing CC235 P. aeruginosa clinical isolates have spread in medical settings throughout Japan.
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页数：9
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