Sulphonamide-based small molecule VLA-4 antagonists

被引：3

作者：

Stasiak, M ^{[1
]}

Mehlin, C ^{[1
]}

Boni, E ^{[1
]}

Vaisar, T ^{[1
]}

Little, T ^{[1
]}

Kim, HO ^{[1
]}

Qabar, M ^{[1
]}

机构：

[1] Molecumet, Bellevue, WA 98005 USA

来源：

BIOORGANIC & MEDICINAL CHEMISTRY LETTERS | 2003年 / 13卷 / 21期

关键词：

D O I：

10.1016/S0960-894X(03)00760-1

中图分类号：

R914 [药物化学];

学科分类号：

100701 ;

摘要：

The discovery of a sulphonamide by-product with VLA-4 antagonistic activity led to a series of potent, small molecule VLA-4 antagonists. Synthesis, SAR and in vivo evaluation of the selected compound will be presented. (C) 2003 Elsevier Ltd. All rights reserved.

引用

页码：3875 / 3878

页数：4

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