Nuclear proteins: finding and binding target sites in chromatin

被引：39
|
作者：
van Royen, Martin E. [1 ]
Zotter, Angelika [1 ]
Ibrahim, Shehu M. [1 ]
Geverts, Bart [1 ]
Houtsmuller, Adriaan B. [1 ]
机构：
[1] Erasmus Univ, Med Ctr, Dept Pathol, Josephine Nefkens Inst, NL-3000 CA Rotterdam, Netherlands
来源：
CHROMOSOME RESEARCH | 2011年 / 19卷 / 01期
关键词：
binding models; FRAP; high mobility; transient chromatin binding; diffusion; transcription; DNA repair; RNA-POLYMERASE-II; RESTRICTION-ENDONUCLEASE ECORV; ONE-DIMENSIONAL DIFFUSION; LIGAND-SPECIFIC DYNAMICS; ESTROGEN-RECEPTOR-ALPHA; DNA-REPAIR PROTEIN; IN-VIVO DYNAMICS; FLUORESCENCE RECOVERY; ANDROGEN RECEPTOR; GLUCOCORTICOID-RECEPTOR;
D O I：
10.1007/s10577-010-9172-5
中图分类号：
Q5 [生物化学]; Q7 [分子生物学];
学科分类号：
071010 ; 081704 ;
摘要：
Fluorescent protein labelling, as well as impressive progress in live cell imaging have revolutionised the view on how essential nuclear functions like gene transcription regulation and DNA repair are organised. Here, we address questions like how DNA-interacting molecules find and bind their target sequences in the vast amount of DNA. In addition, we discuss methods that have been developed for quantitative analysis of data from fluorescence recovery after photobleaching experiments (FRAP).
引用
收藏
页码：83 / 98
页数：16
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