Antioxidant Vitamins and Their Use in Preventing Cardiovascular Disease

被引：73

作者：

Farbstein, Dan ^{[1
]}

Kozak-Blickstein, Adena ^{[1
]}

Levy, Andrew P. ^{[1
]}

机构：

[1] Technion Israel Inst Technol, Technion Fac Med, Haifa, Israel

来源：

MOLECULES | 2010年 / 15卷 / 11期

基金：

美国国家卫生研究院;

关键词：

vitamin E; antioxidants; vitamin C; atherosclerosis; CVD; ENDOTHELIUM-DEPENDENT VASODILATION; ACTIVATED HUMAN MONOCYTES; CELL-ADHESION MOLECULE-1; LOW-DENSITY-LIPOPROTEIN; NECROSIS-FACTOR-ALPHA; E SUPPLEMENTATION; TRANSFER PROTEIN; TOCOPHEROL; EXPRESSION; INHIBITION;

D O I：

10.3390/molecules15118098

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

Atherosclerosis remains one of the leading causes of death in Western populations. Subsequent to the discovery that oxidative stress plays a pivotal role in the development and progression of atherosclerosis, vitamins C and E, along with other antioxidants, were studied as potential therapies for the disease. However, while in vitro and in vivo studies showed promising antiatherogenic effects for vitamins C and E, clinical trials in which patients were given high doses of vitamin E or C showed no benefit and even possible harm. This review will attempt to summarize the known mechanistic data regarding the biochemical effects of vitamins C and E and their relevance to atherosclerosis, and offer an explanation for the failure of clinical trials to show that supplementation with these vitamins provides any benefit when given indiscriminately. We provide one example of how pharmacogenomics may be used to identify a sub-population which may indeed benefit from antioxidant supplementation.

引用

页码：8098 / 8110

页数：13

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