Introduction and methods of the evidence-based guidelines for the diagnosis and management of autism spectrum disorder by the Italian National Institute of Health

被引：10

作者：

Morgano, Gian Paolo ^{[1
,2
]}

Fulceri, Francesca ^{[3
]}

Nardocci, Franco ^{[3
]}

Barbui, Corrado ^{[4
]}

Ostuzzi, Giovanni ^{[4
]}

Papola, Davide ^{[4
,5
,6
]}

Fatta, Laura Maria ^{[3
]}

Fauci, Alice Josephine ^{[7
]}

Coclite, Daniela ^{[7
]}

Napoletano, Antonello ^{[7
]}

De Crescenzo, Franco ^{[8
,9
]}

D'Alo, Gian Loreto ^{[8
,10
]}

Amato, Laura ^{[8
]}

Cinquini, Michela ^{[11
]}

Iannone, Primiano ^{[7
]}

Schunemann, Holger Jens ^{[1
,2
,12
]}

Scattoni, Maria Luisa ^{[3
]}

机构：

[1] McMaster Univ, Michael G DeGroote Cochrane Canada Ctr, 1280 Main St West, Hamilton, ON, Canada

[2] McMaster Univ, McMaster GRADE Ctr, Dept Hlth Res Methods Evidence & Impact, 1280 Main St West, Hamilton, ON, Canada

[3] Ist Super Sanita, Res Coordinat & Support Serv, Viale Regina Elena 299, I-00161 Rome, Italy

[4] Univ Verona, Sect Psychiat, Dept Neurosci Biomed & Movement Sci, WHO Collaborating Ctr Res & Training Mental Hlth, Verona, Italy

[5] Vrije Univ, Dept Clin Neuro & Dev Psychol, Amsterdam, Netherlands

[6] Vrije Univ, Fac Behav & Movement Sci, Amsterdam, Netherlands

[7] Ist Super Sanita, Ctr Eccellenza Clin Qualita & Sicurezza Cure, Viale Regina Elena 299, I-00161 Rome, Italy

[8] Lazio Reg Hlth Serv, Dept Epidemiol, Via Cristoforo Colombo 112, I-00154 Rome, Italy

[9] Univ Oxford, Dept Psychiat, Oxford, England

[10] Univ Roma Tor Vergata, Sch Hyg & Prevent Med, Rome, Italy

[11] Mario Negri Inst Pharmacol Res IRCCS, Via Giuseppe La Masa 19, I-20156 Milan, Italy

[12] McMaster Univ, Dept Med, Hamilton, ON, Canada

来源：

HEALTH AND QUALITY OF LIFE OUTCOMES | 2020年 / 18卷 / 01期

关键词：

Autism Spectrum disorder; Italian National Institute of health; Italian national guidelines system; GRADE approach; Healthcare decision; Diagnosis; Treatment; Recommendations; Guideline; INTERNATIONAL NETWORK; FINDINGS TABLES; GRADE; RECOMMENDATIONS; STRENGTH; QUALITY;

D O I：

10.1186/s12955-020-01320-4

中图分类号：

R19 [保健组织与事业（卫生事业管理）];

学科分类号：

摘要：

Background Autism Spectrum Disorder (ASD) is a neuro-developmental disorder that affects communication and behavior with a prevalence of approximately 1% worldwide. Health outcomes of interventions for ASD are largely Participant Reported Outcomes (PROs). Specific guidelines can help support the best care for people with ASD to optimize these health outcomes but they have to adhere to standards for their development to be trustworthy. Objective The goal of this article is to describe the new methodological standards of the Italian National Institute of Health and novel aspects of this guideline development process. This article will serve as a reference standard for future guideline development in the Italian setting. Methods We applied the new standards of the Italian National Institute of Health to the two guidelines on diagnosis and management of children/adolescents and adults with ASD, with a focus on the scoping, panel composition, management of conflict of interest, generation and prioritization of research questions, early stakeholders' involvement, and PROs. Recommendations are based on the Grading of Recommendations Assessment, Development and Evaluation (GRADE) Evidence-to-Decision frameworks. Results Following a public application process, the ISS established two multidisciplinary panels including people with ASD and/or their caregivers. Seventy-nine research questions were identified as potentially relevant for the guideline on children and adolescents with ASD and 31 for the one on adults with ASD. Questions deemed to have the highest priority were selected for inclusion in the guidelines. Other stakeholders valued their early involvement in the process which will largely focus on PROs. The panels then successfully piloted the development of recommendations using the methodological standards and process set by the ISS with a focus on PROs. Conclusions In this article, we describe the development of practice guidelines that focus on PROs for the diagnosis and management of ASD based on novel methods for question prioritization and stakeholder involvement. The recommendations allow for the adoption or adaptation to international settings.

引用

页数：12