Bioorthogonal chemistry in bioluminescence imaging

被引：17

作者：

Godinat, Aurelien ^{[1
]}

Bazhin, Arkadiy A. ^{[2
]}

Goun, Elena A. ^{[2
]}

机构：

[1] Imperial Coll London, Dept Chem, Inst Chem Biol, London SW7 2AZ, England

[2] Ecole Polytech Fed Lausanne, Swiss Fed Inst Technol Lausanne, Lab Bioorgan Chem & Mol Imaging, Inst Chem Sci & Engn ISIC, CH-1015 Lausanne, Switzerland

来源：

DRUG DISCOVERY TODAY | 2018年 / 23卷 / 09期

关键词：

BIOCOMPATIBLE CONDENSATION REACTION; IN-VIVO; HYDROGEN-SULFIDE; FIREFLY LUCIFERASE; CASPASE ACTIVITY; LIVING SUBJECTS; GLYCOSYLATION; DISEASE; MICE; AMINOLUCIFERIN;

D O I：

10.1016/j.drudis.2018.05.022

中图分类号：

R9 [药学];

学科分类号：

1007 ;

摘要：

Bioorthogonal chemistry has developed significant over the past few decades, to the particular benefit of molecular imaging. Bioluminescence imaging (BLI) along with other imaging modalities have significantly benefitted from this chemistry. Here, we review bioorthogonal reactions that have been used to signific antly broaden the application range of BLI.

引用

页码：1584 / 1590

页数：7

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