ATM Is Required for the Repair of Oxaliplatin-Induced DNA Damage in Colorectal Cancer

被引:16
作者
Bakkenist, Christopher J. [1 ,2 ]
Lee, James J. [3 ]
Schmitz, John C. [3 ]
机构
[1] Univ Pittsburgh, Sch Med, UPMC Hillman Canc Ctr, Dept Radiat Oncol, 5117 Ctr Ave, Pittsburgh, PA 15213 USA
[2] Univ Pittsburgh, Sch Med, UPMC Hillman Canc Ctr, Dept Pharmacol & Chem Biol, Pittsburgh, PA USA
[3] Univ Pittsburgh, Sch Med, UPMC Hillman Canc Ctr, Dept Med, Pittsburgh, PA USA
基金
美国国家卫生研究院;
关键词
COLON-CANCER; SYNTHETIC LETHALITY; ADJUVANT; CELLS; FLUOROURACIL; LEUCOVORIN; INHIBITION; MUTATIONS; THERAPY;
D O I
10.1016/j.clcc.2018.09.001
中图分类号
R73 [肿瘤学];
学科分类号
100214 ;
摘要
引用
收藏
页码:255 / 257
页数:3
相关论文
共 18 条
[1]   Oxaliplatin, fluorouracil, and leucovorin as adjuvant treatment for colon cancer [J].
Andre, T ;
Boni, C ;
Mounedji-Boudiaf, L ;
Navarro, M ;
Tabernero, J ;
Hickish, T ;
Topham, C ;
Zaninelli, M ;
Clingan, P ;
Bridgewater, J ;
Tabah-Fisch, I ;
de Gramont, A .
NEW ENGLAND JOURNAL OF MEDICINE, 2004, 350 (23) :2343-2351
[2]   Radiation therapy induces the DNA damage response in peripheral blood [J].
Bakkenist, Christopher J. ;
Czambel, R. Kenneth ;
Clump, David A. ;
Greenberger, Joel S. ;
Beumer, Jan H. ;
Schmitz, John C. .
ONCOTARGET, 2013, 4 (08) :1143-1148
[3]   DNA damage activates ATM through intermolecular autophosphorylation and dimer dissociation [J].
Bakkenist, CJ ;
Kastan, MB .
NATURE, 2003, 421 (6922) :499-506
[4]   Loss of expression of ATM is associated with worse prognosis in colorectal cancer and loss of Ku70 expression is associated with CIN [J].
Beggs, Andrew D. ;
Domingo, Enric ;
McGregor, Megan ;
Presz, Mikael ;
Johnstone, Elaine ;
Midgley, Rachel ;
Kerr, David ;
Oukrif, Dahmane ;
Novelli, Marco ;
Abulafi, Muti ;
Hodgson, Shirley V. ;
Fadhil, Wakkas ;
Ilyas, Mohammad ;
Tomlinson, Ian P. M. .
ONCOTARGET, 2012, 3 (11) :1348-1355
[5]   ATM Mutations in Cancer: Therapeutic Implications [J].
Choi, Michael ;
Kipps, Thomas ;
Kurzrock, Razelle .
MOLECULAR CANCER THERAPEUTICS, 2016, 15 (08) :1781-1791
[6]   Brd4 Shields Chromatin from ATM Kinase Signaling Storms [J].
Choi, Serah ;
Bakkenist, Christopher J. .
SCIENCE SIGNALING, 2013, 6 (293)
[7]   Synthetic lethality screening reveals ATR as responsible for oxaliplatin resistance in colorectal cancer cells [J].
Combes, Eve ;
Faria-Andrade, Augusto ;
Tosi, Diego ;
Martineau, Pierre ;
Del Rio, Maguy ;
Beijersbergen, Roderick ;
Vie, Nadia ;
Gongora, Celine .
CANCER RESEARCH, 2017, 77
[8]   Leucovorin and fluorouracil with or without oxaliplatin as first-line treatment in advanced colorectal cancer [J].
de Gramont, A ;
Figer, A ;
Seymour, M ;
Homerin, M ;
Hmissi, A ;
Cassidy, J ;
Boni, C ;
Cortes-Funes, H ;
Cervantes, A ;
Freyer, G ;
Papamichael, D ;
Le Bail, N ;
Louvet, C ;
Hendler, D ;
de Braud, F ;
Wilson, C ;
Morvan, F ;
Bonetti, A .
JOURNAL OF CLINICAL ONCOLOGY, 2000, 18 (16) :2938-2947
[9]   The novel ATM inhibitor (AZ31) enhances antitumor activity in patient derived xenografts that are resistant to irinotecan monotherapy [J].
Greene, Justin ;
Nguyen, Anna ;
Bagby, Stacey M. ;
Jones, Gemma N. ;
Tai, Wm. ;
Quackenbush, Kevin S. ;
Schreiber, Anna ;
Messersmith, Wells A. ;
Devaraj, Kalpana M. ;
Blatchford, Patrick ;
Eckhardt, S. Gail ;
Cadogan, Elaine B. ;
Hughes, Gareth D. ;
Smith, Aaron ;
Pitts, Todd M. ;
Arcaroli, John J. .
ONCOTARGET, 2017, 8 (67) :110904-110913
[10]   Capecitabine Plus Oxaliplatin Compared With Fluorouracil and Folinic Acid As Adjuvant Therapy for Stage III Colon Cancer [J].
Haller, Daniel G. ;
Tabernero, Josep ;
Maroun, Jean ;
de Braud, Filippo ;
Price, Timothy ;
Van Cutsem, Eric ;
Hill, Mark ;
Gilberg, Frank ;
Rittweger, Karen ;
Schmoll, Hans-Joachim .
JOURNAL OF CLINICAL ONCOLOGY, 2011, 29 (11) :1465-1471