The role of constitutive activation of FMS-related tyrosine kinase-3 and NRas/KRas mutational status in infants with KMT2A-rearranged acute lymphoblastic leukemia

被引：14

作者：

Fedders, Henning ^{[1
,2
]}

Alsadeq, Ameera ^{[1
,2
]}

Schmaeh, Juliane ^{[1
,2
]}

Vogiatzi, Fotini ^{[1
,2
]}

Zimmermann, Martin ^{[3
]}

Moericke, Anja ^{[1
,2
]}

Lenk, Lennart ^{[1
,2
]}

zur Stadt, Udo ^{[4
,5
]}

Horstmann, Martin A. ^{[4
,5
]}

Pieters, Rob ^{[6
]}

Schrappe, Martin ^{[1
,2
]}

Stanulla, Martin ^{[3
]}

Cario, Gunnar ^{[1
,2
]}

Schewe, Denis M. ^{[1
,2
]}

机构：

[1] Christian Albrechts Univ Kiel, Dept Pediat, Kiel, Germany

[2] Univ Med Ctr Schleswig Holstein, Kiel, Germany

[3] Hannover Med Sch, Pediat Hematol & Oncol, Hannover, Germany

[4] Univ Med Ctr Hamburg Eppendorf, Res Inst Childrens Canc Ctr, Hamburg, Germany

[5] Univ Med Ctr Hamburg Eppendorf, Clin Pediat Hematol & Oncol, Hamburg, Germany

[6] Princess Maxima Ctr Pediat Oncol, Utrecht, Netherlands

来源：

HAEMATOLOGICA | 2017年 / 102卷 / 11期

关键词：

PROGNOSTIC-SIGNIFICANCE; RAS MUTATIONS; MLL; FLT3; EXPRESSION; REARRANGEMENTS; LOOP;

D O I：

10.3324/haematol.2017.169870

中图分类号：

R5 [内科学];

学科分类号：

1002 ; 100201 ;

摘要：

引用

页码：E438 / E442

页数：5

共 15 条

[1] The landscape of somatic mutations in infant MLL-rearranged acute lymphoblastic leukemias [J].

Andersson, Anna K. ;

Ma, Jing ;

Wang, Jianmin ;

Chen, Xiang ;

Gedman, Amanda Larson ;

Dang, Jinjun ;

Nakitandwe, Joy ;

Holmfeldt, Linda ;

Parker, Matthew ;

Easton, John ;

Huether, Robert ;

Kriwacki, Richard ;

Rusch, Michael ;

Wu, Gang ;

Li, Yongjin ;

Mulder, Heather ;

Raimondi, Susana ;

Pounds, Stanley ;

Kang, Guolian ;

Shi, Lei ;

Becksfort, Jared ;

Gupta, Pankaj ;

Payne-Turner, Debbie ;

Vadodaria, Bhavin ;

Boggs, Kristy ;

Yergeau, Donald ;

Manne, Jayanthi ;

Song, Guangchun ;

Edmonson, Michael ;

Nagahawatte, Panduka ;

Wei, Lei ;

Cheng, Cheng ;

Pei, Deqing ;

Sutton, Rosemary ;

Venn, Nicola C. ;

Chetcuti, Albert ;

Rush, Amanda ;

Catchpoole, Daniel ;

Heldrup, Jesper ;

Fioretos, Thoas ;

Lu, Charles ;

Ding, Li ;

Pui, Ching-Hon ;

Shurtleff, Sheila ;

Mullighan, Charles G. ;

Mardis, Elaine R. ;

Wilson, Richard K. ;

Gruber, Tanja A. ;

Zhang, Jinghui ;

Downing, James R. .

NATURE GENETICS, 2015, 47 (04) :330-U192

[2] The biology and targeting of FLT3 in pediatric leukemia [J].

Annesley, Colleen E. ;

Brown, Patrick .

FRONTIERS IN ONCOLOGY, 2014, 4

[3] Inhibition of FLT3 in MLL: Validation of a therapeutic target identified by gene expression based classification [J].

Armstrong, SA ;

Kung, AL ;

Mabon, ME ;

Silverman, LB ;

Stam, RW ;

Den Boer, ML ;

Pieters, R ;

Kersey, JH ;

Sallan, SE ;

Fletcher, JA ;

Golub, TR ;

Griffin, JD ;

Korsmeyer, SJ .

CANCER CELL, 2003, 3 (02) :173-183

[4] MLL translocations specify a distinct gene expression profile that distinguishes a unique leukemia [J].

Armstrong, SA ;

Staunton, JE ;

Silverman, LB ;

Pieters, R ;

de Boer, ML ;

Minden, MD ;

Sallan, SE ;

Lander, ES ;

Golub, TR ;

Korsmeyer, SJ .

NATURE GENETICS, 2002, 30 (01) :41-47

[5]

Brown PK, 2016, PEDIAT BLOOD CANC, V63, pS321

[6] Prognostic significance of FLT3 mutational status and expression levels in MLL-AF4+and MLL-germline acute lymphoblastic leukemia [J].

Chillon, M. C. ;

Gomez-Casares, M. T. ;

Lopez-Jorge, C. E. ;

Rodriguez-Medina, C. ;

Molines, A. ;

Sarasquete, M. E. ;

Alcoceba, M. ;

Miguel, J. D. G-S ;

Bueno, C. ;

Montes, R. ;

Ramos, F. ;

Rodriguez, J. N. ;

Giraldo, P. ;

Ramirez, M. ;

Garcia-Delgado, R. ;

Fuster, J. L. ;

Gonzalez-Diaz, M. ;

Menendez, P. .

LEUKEMIA, 2012, 26 (11) :2360-2366

[7] Frequencies and prognostic impact of RAS mutations in MLL-rearranged acute lymphoblastic leukemia in infants [J].

Driessen, Emma M. C. ;

van Roon, Eddy H. J. ;

Spijkers-Hagelstein, Jill A. P. ;

Schneider, Pauline ;

de Lorenzo, Paola ;

Valsecchi, Maria Grazia ;

Pieters, Rob ;

Stam, Ronald W. .

HAEMATOLOGICA, 2013, 98 (06) :937-944

[8] Sensitivity toward tyrosine kinase inhibitors varies between different activating mutations of the FLT3 receptor [J].

Grundler, R ;

Thiede, C ;

Miething, C ;

Steudel, C ;

Peschel, C ;

Duyster, J .

BLOOD, 2003, 102 (02) :646-651

[9] Gene expression profiles predictive of outcome and age in infant acute lymphoblastic leukemia: a Children's Oncology Group study [J].

Kang, Huining ;

Wilson, Carla S. ;

Harvey, Richard C. ;

Chen, I. -Ming ;

Murphy, Maurice H. ;

Atlas, Susan R. ;

Bedrick, Edward J. ;

Devidas, Meenakshi ;

Carroll, Andrew J. ;

Robinson, Blaine W. ;

Stam, Ronald W. ;

Valsecchi, Maria G. ;

Pieters, Rob ;

Heerema, Nyla A. ;

Hilden, Joanne M. ;

Felix, Carolyn A. ;

Reaman, Gregory H. ;

Camitta, Bruce ;

Winick, Naomi ;

Carroll, William L. ;

Dreyer, ZoAnn E. ;

Hunger, Stephen P. ;

Willman, Cheryl L. .

BLOOD, 2012, 119 (08) :1872-1881

[10] K-Ras mutations and N-Ras mutations in childhood acute leukemias with or without mixed-lineage leukemia gene rearrangements [J].

Liang, DC ;

Shih, LY ;

Fu, JF ;

Li, HY ;

Wang, HI ;

Hung, IJ ;

Yang, CP ;

Jaing, TH ;

Chen, SH ;

Liu, HC .

CANCER, 2006, 106 (04) :950-956

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