Noncoding RNAs in the brain

被引：35

作者：

Satterlee, John S.

Barbee, Scott

Jin, Peng

Krichevsky, Anna

Salama, Sofie

Schratt, Gerhard

Wu, Da-Yu

机构：

[1] Natl Inst Drug Abuse, Div Basic Neurosci & Behav Res, Bethesda, MD 20892 USA

[2] Univ Denver, Dept Biol Sci, Denver, CO 80208 USA

[3] Emory Univ, Sch Med, Dept Human Genet, Atlanta, GA 30322 USA

[4] Harvard Univ, Brigham & Womens Hosp, Sch Med, Neurol Ctr Neurol Dis, Boston, MA 02115 USA

[5] Univ Calif Santa Cruz, Ctr Biomol Engn, Santa Cruz, CA 95064 USA

[6] Heidelberg Univ, Interdisciplinary Ctr Neurosci, D-69120 Heidelberg, Germany

来源：

JOURNAL OF NEUROSCIENCE | 2007年 / 27卷 / 44期

关键词：

brain development; CREB; dendritic spine; development; differentiation; epigenetic; human forebrain development; learning and memory; neurogenesis; Purkinje neurons; RNA; synaptic plasticity;

D O I：

10.1523/JNEUROSCI.3624-07.2007

中图分类号：

Q189 [神经科学];

学科分类号：

071006 ;

摘要：

Cells transcribe thousands of RNAs that do not appear to encode proteins. The neuronal functions of these noncoding RNAs(ncRNAs) are for the most part not known, but specific ncRNAs have been shown to regulate dendritic spine development, neuronal fate specification and differentiation, and synaptic protein synthesis. ncRNAs have been implicated in a number of neuronal diseases including Tourette's syndrome and Fragile X syndrome. Future studies will likely identify additional neuronal functions for ncRNAs as well as roles for these molecules in other neuropsychiatric and neurodevelopmental disorders.

引用

收藏

页码：11856 / 11859

页数：4

相关论文

共 42 条

[1] Sequence variants in SLITRK1 are associated with Tourette's syndrome [J].

Abelson, JF ;

Kwan, KY ;

O'Roak, BJ ;

Baek, DY ;

Stillman, AA ;

Morgan, TM ;

Mathews, CA ;

Pauls, DA ;

Rasin, MR ;

Gunel, M ;

Davis, NR ;

Ercan-Sencicek, AG ;

Guez, DH ;

Spertus, JA ;

Leckman, JF ;

Dure, LS ;

Kurlan, R ;

Singer, HS ;

Gilbert, DL ;

Farhi, A ;

Louvi, A ;

Lifton, RP ;

Sestan, N ;

State, MW .

SCIENCE, 2005, 310 (5746) :317-320

[2] Synaptic protein synthesis associated with memory is regulated by the RISC pathway in Drosophila [J].

Ashraf, SI ;

McLoon, AL ;

Sclarsic, SM ;

Kunes, S .

CELL, 2006, 124 (01) :191-205

[3] Staufen- and FMRP-containing neuronal RNPs are structurally and functionally related to somatic P bodies [J].

Barbee, Scott A. ;

Estes, Patricia S. ;

Cziko, Anne-Marie ;

Hillebrand, Jens ;

Luedeman, Rene A. ;

Coller, Jeff M. ;

Johnson, Nick ;

Howlett, Iris C. ;

Geng, Cuiyun ;

Ueda, Ryu ;

Brand, Andrea H. ;

Newbury, Sarah F. ;

Wilhelm, James E. ;

Levine, Richard B. ;

Nakamura, Akira ;

Parker, Roy ;

Ramaswami, Mani .

NEURON, 2006, 52 (06) :997-1009

[4] MicroRNAs: Genomics, biogenesis, mechanism, and function (Reprinted from Cell, vol 116, pg 281-297, 2004) [J].

Bartel, David P. .

CELL, 2007, 131 (04) :11-29

[5] Camels and zebrafish, viruses and cancer: a microRNA update [J].

Berezikov, E ;

Plasterk, RHA .

HUMAN MOLECULAR GENETICS, 2005, 14 :R183-R190

[6] Diversity of microRNAs in human and chimpanzee brain [J].

Berezikov, Eugene ;

Thuemmler, Fritz ;

van Laake, Linda W. ;

Kondova, Ivanela ;

Bontrop, Ronald ;

Cuppen, Edwin ;

Plasterk, Ronald H. A. .

NATURE GENETICS, 2006, 38 (12) :1375-1377

[7] MicroRNA pathways modulate polyglutamine-induced neurodegeneration [J].

Bilen, Julide ;

Liu, Nan ;

Burnett, Barrington G. ;

Pittman, Randall N. ;

Bonini, Nancy M. .

MOLECULAR CELL, 2006, 24 (01) :157-163

[8] A functional study of miR-124 in the developing neural tube [J].

Cao, Xinwei ;

Pfaff, Samuel L. ;

Gage, Fred H. .

GENES & DEVELOPMENT, 2007, 21 (05) :531-536

[9]

Cao XW, 2006, ANNU REV NEUROSCI, V29, P77, DOI 10.1146/annurev.neuro.29.051605.112839

[10] The many faces of CREB [J].

Carlezon, WA ;

Duman, RS ;

Nestler, EJ .

TRENDS IN NEUROSCIENCES, 2005, 28 (08) :436-445

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