Alcohol-triggered signs of migraine: An animal model

被引：4

作者：

Alabwah, Yaqoub ^{[1
]}

Ji, Yadong ^{[1
]}

Seminowicz, David A. ^{[2
,3
]}

Quiton, Raimi L. ^{[2
,4
,5
]}

Masri, Radi ^{[1
,3
,5
]}

机构：

[1] Univ Maryland, Sch Dent, Dept Endodont Prosthodont & Operat Dent, 650 W Baltimore St Off,6253, Baltimore, MD 21201 USA

[2] Univ Maryland, Sch Dent, Dept Neural & Pain Sci, Baltimore, MD 21201 USA

[3] Univ Maryland, Program Neurosci, Baltimore, MD 21201 USA

[4] Univ Maryland Baltimore Cty, Dept Psychol, Baltimore, MD 21228 USA

[5] Univ Maryland, Sch Med, Dept Anat & Neurobiol, Baltimore, MD 21201 USA

来源：

SOMATOSENSORY AND MOTOR RESEARCH | 2016年 / 33卷 / 01期

关键词：

Migraine; headache; trigeminal; CORTICAL SPREADING DEPRESSION; CUTANEOUS ALLODYNIA; CENTRAL PAIN; HEADACHE; WINE; RED; SENSITIZATION; RATS; STIMULATION; PROJECTIONS;

D O I：

10.3109/08990220.2016.1163258

中图分类号：

Q189 [神经科学];

学科分类号：

071006 ;

摘要：

We describe an animal model where characteristics of migraine can be triggered by alcohol administration. In rats chronically implanted with a cannula overlying the transverse sinus, we applied potassium chloride (KCl) (or saline) to the meninges to sensitize trigeminovascular afferents. We assessed effects of repeated KCl application on animal behavior using conditioned place avoidance paradigm. In KCl-treated rats we discovered that alcohol injections (0.2 mg/kg), but not saline, resulted in the development of extracephalic allodynia and signs of ongoing pain.

引用

页码：35 / 41

页数：7

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